@article{b7861c0c5e774bf78d1786af06f7c0b3,
title = "Huntington's Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy",
abstract = "Fox et al. demonstrate in a Huntington's disease (HD) mouse model and HD-patient-derived neurons that the autophagy adaptor protein Alfy/WDFY3 is required for removal of aggregated protein and that depletion of Alfy hastens the pathogenic onset of HD.",
keywords = "Alfy, Huntington's disease, Wdfy3, autophagy, direct conversion, mice, neurodegeneration, patient fibroblasts, proteinopathy, selective autophagy",
author = "Fox, {Leora M.} and Kiryung Kim and Johnson, {Christopher W.} and Shawei Chen and Croce, {Katherine R.} and Victor, {Matheus B.} and Evelien Eenjes and Bosco, {Joan R.} and Randolph, {Lisa K.} and Ioannis Dragatsis and Dragich, {Joanna M.} and Yoo, {Andrew S.} and Ai Yamamoto",
note = "Funding Information: The authors would like to acknowledge and thank Drs. Robert Burke and Christoph Kellendonk and their lab members for technical guidance and support and Drs. Dritan Agalliu, Robert Burke, Tyler Cutforth, Lisa Ellerby, Lloyd Greene, Christoph Kellendonk, and members of the Yamamoto lab for helpful discussions. A special thanks to Katharine Abbot and William Jackson Lovejoy for their contributions and Drs. Gillian Bates and Masaaki Komatsu for use of antibodies created in their labs. This work was supported by the Hereditary Disease Foundation (L.M.F., K.R.C., and A.Y.); NINDS grants R01 NS063973 (J.R.B., E.E., C.W.J., and A.Y.), R01 NS077111 (J.M.D., L.M.F., and A.Y.), and R01 NS107488 (S.C. and A.S.Y.); a Huntington's Disease Society of America Donald King Summer Research Fellowship (K.K.); a Ruth L. Kirschstein NRSA predoctoral fellowship (L.M.F.); grant T32 NS064928 (L.M.F.); and an NSF predoctoral fellowship (K.R.C.). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2020",
month = mar,
day = "4",
doi = "10.1016/j.neuron.2019.12.003",
language = "English",
volume = "105",
pages = "813--821.e6",
journal = "Neuron",
issn = "0896-6273",
number = "5",
}