Purpose of review: This article summarizes the current pathophysiologic basis for human T cell lymphotropic virus-associated leukemia/lymphoma as well as past, present, and future therapeutic options. Recent findings: New studies have been published on allogeneic stem cell transplantation, arsenic trioxide, and bortezomib for this condition. Summary: Studies of the molecular biology of human T cell lymphotropic virus-1-induced T cell leukemia/lymphoma have defined a critical role for oncoprotein, Tax, and activation of nuclear factor κB transcription pathways, which have provided rational approaches to improved therapy for T cell leukemia/lymphoma as well as a model for other hematopoietic malignancies characterized by nuclear factor κB activation.
|Number of pages||5|
|Journal||Current Opinion in Oncology|
|State||Published - Sep 2005|
- Human T cell leukemia/lymphoma
- T cell leukemia/lymphoma