Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species

Jichang Han, Alexandre Gallerand, Emma C. Erlich, Beth A. Helmink, Iris Mair, Xin Li, Shaina R. Eckhouse, Francesca M. Dimou, Baddr A. Shakhsheer, Hannah M. Phelps, Mandy M. Chan, Rachel L. Mintz, Daniel D. Lee, Joel D. Schilling, Conor M. Finlay, Judith E. Allen, Claudia V. Jakubzick, Kathryn J. Else, Emily J. Onufer, Nan ZhangGwendalyn J. Randolph

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In mouse peritoneal and other serous cavities, the transcription factor GATA6 drives the identity of the major cavity resident population of macrophages, with a smaller subset of cavity-resident macrophages dependent on the transcription factor IRF4. Here we showed that GATA6 + macrophages in the human peritoneum were rare, regardless of age. Instead, more human peritoneal macrophages aligned with mouse CD206+ LYVE1+ cavity macrophages that represent a differentiation stage just preceding expression of GATA6. A low abundance of CD206+ macrophages was retained in C57BL/6J mice fed a high-fat diet and in wild-captured mice, suggesting that differences between serous cavity-resident macrophages in humans and mice were not environmental. IRF4-dependent mouse serous cavity macrophages aligned closely with human CD1c+CD14+CD64+ peritoneal cells, which, in turn, resembled human peritoneal CD1c+CD14CD64 cDC2. Thus, major populations of serous cavity-resident mononuclear phagocytes in humans and mice shared common features, but the proportions of different macrophage differentiation stages greatly differ between the two species, and dendritic cell (DC2)-like cells were especially prominent in humans.

Original languageEnglish
Pages (from-to)155-165
Number of pages11
JournalNature immunology
Volume25
Issue number1
DOIs
StatePublished - Jan 2024

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