Human recombinant interleukin-1 receptor antagonist blocks bone resorption induced by interleukin-1β but not interleukin-1α

R. A. Chole, S. P. Tinling, B. T. Faddis

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Both interleukin-1α (IL-1α) and interleukin-1β (IL-1β) are powerful stimulators of bone resorption in vivo and in vitro. Interleukin-1 receptor antagonist (IL-1ra) binds to many interleukin-1 receptors. It does not activate the receptor and effectively blocks the action of IL-1α and IL-1β. In this study, human recombinant IL-1ra, at 100-fold excess, was found to block bone resorption in cultured mouse calvaria due to IL-1β but not IL-1α. These observations may be explained by differential affinities of receptors for IL-1α, IL-1β and rhIL-1ra on target bone cells.

Original languageEnglish
Pages (from-to)12-15
Number of pages4
JournalCalcified Tissue International
Volume55
Issue number1
DOIs
StatePublished - Jul 1994

Keywords

  • Bone
  • Calcium
  • IL-1 receptor antagonist
  • IL-1α
  • IL-1β
  • Parathyroid hormone

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