TY - JOUR
T1 - Human protease-activated receptor 1 expression in malignant epithelia
T2 - A role in invasiveness
AU - Yin, Yong Jun
AU - Salah, Zaidoun
AU - Grisaru-Granovsky, Sorina
AU - Cohen, Irit
AU - Even-Ram, Sharona Cohen
AU - Maoz, Myriam
AU - Uziely, Beatrice
AU - Peretz, Tamar
AU - Bar-Shavit, Rachel
PY - 2003/6/1
Y1 - 2003/6/1
N2 - While protease-activated receptors (PARs) play a traditional role in vascular biology, they emerge with surprisingly new assignments in tumor biology. PAR1 expression correlates with the invasion properties of breast carcinoma, whereas human PAR1 antisense reduces their ability to migrate through Matrigel. Part of the molecular mechanism of PAR1 invasion involves the formation of focal contact complexes on PAR1 activation. PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands.
AB - While protease-activated receptors (PARs) play a traditional role in vascular biology, they emerge with surprisingly new assignments in tumor biology. PAR1 expression correlates with the invasion properties of breast carcinoma, whereas human PAR1 antisense reduces their ability to migrate through Matrigel. Part of the molecular mechanism of PAR1 invasion involves the formation of focal contact complexes on PAR1 activation. PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands.
KW - Angiogenesis
KW - Epithelia
KW - Invasion
KW - Metastasis
KW - PAR1
UR - http://www.scopus.com/inward/record.url?scp=0037783286&partnerID=8YFLogxK
U2 - 10.1161/01.ATV.0000066878.27340.22
DO - 10.1161/01.ATV.0000066878.27340.22
M3 - Review article
C2 - 12637343
AN - SCOPUS:0037783286
SN - 1079-5642
VL - 23
SP - 940
EP - 944
JO - Arteriosclerosis, thrombosis, and vascular biology
JF - Arteriosclerosis, thrombosis, and vascular biology
IS - 6
ER -