Human pain neuroscience and the next generation of pain therapeutics

NIH PRECISION Human Pain Network

doi:10.1016/j.neuron.2025.04.005

Human pain neuroscience and the next generation of pain therapeutics

NIH PRECISION Human Pain Network

Research output: Contribution to journal › Comment/debate

3 Scopus citations

Abstract

The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies primarily in human-based systems. To realize this transformative potential, further research into somatosensation and pain neuroimmunology in human systems is essential.

Original language	English
Pages (from-to)	1304-1306
Number of pages	3
Journal	Neuron
Volume	113
Issue number	9
DOIs	https://doi.org/10.1016/j.neuron.2025.04.005
State	Published - May 7 2025

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10.1016/j.neuron.2025.04.005

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title = "Human pain neuroscience and the next generation of pain therapeutics",

abstract = "The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies primarily in human-based systems. To realize this transformative potential, further research into somatosensation and pain neuroimmunology in human systems is essential.",

author = "\{NIH PRECISION Human Pain Network\} and Copits, \{Bryan A.\} and Michele Curatolo and Dougherty, \{Patrick M.\} and Gereau, \{Robert W.\} and Wenqin Luo and Maryann Martone and Hakan Olausson and Price, \{Theodore J.\} and William Renthal and Woolf, \{Clifford J.\} and Guoyan Zhao",

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AU - NIH PRECISION Human Pain Network

AU - Copits, Bryan A.

AU - Curatolo, Michele

AU - Dougherty, Patrick M.

AU - Gereau, Robert W.

AU - Luo, Wenqin

AU - Martone, Maryann

AU - Olausson, Hakan

AU - Price, Theodore J.

AU - Renthal, William

AU - Woolf, Clifford J.

AU - Zhao, Guoyan

PY - 2025/5/7

Y1 - 2025/5/7

N2 - The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies primarily in human-based systems. To realize this transformative potential, further research into somatosensation and pain neuroimmunology in human systems is essential.

AB - The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies primarily in human-based systems. To realize this transformative potential, further research into somatosensation and pain neuroimmunology in human systems is essential.

UR - https://www.scopus.com/pages/publications/105003811805

U2 - 10.1016/j.neuron.2025.04.005

DO - 10.1016/j.neuron.2025.04.005

M3 - Comment/debate

C2 - 40339567

AN - SCOPUS:105003811805

SN - 0896-6273

VL - 113

SP - 1304

EP - 1306

JO - Neuron

JF - Neuron

IS - 9

ER -

Human pain neuroscience and the next generation of pain therapeutics

Abstract

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