@article{7924c691fd0a46518c508b37bd65b0e8,
title = "Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection",
abstract = "Neutralizing human monoclonal antibodies (mAbs) against SARS-CoV-2 require Fc effector functions for optimal protection during post-exposure therapy, with intact mAbs reducing SARS-CoV-2 burden and lung disease in rodent models better than LALA-PG loss-of-function Fc variant mAbs and requiring monocytes and CD8+ T cells for optimal clinical and virological benefit.",
keywords = "CD8+ T cells, RNA sequencing, SARS-CoV-2, antibody, effector function, lung, monocytes, mouse model, pathogenesis, therapy",
author = "Winkler, \{Emma S.\} and Pavlo Gilchuk and Jinsheng Yu and Bailey, \{Adam L.\} and Chen, \{Rita E.\} and Zhenlu Chong and Zost, \{Seth J.\} and Hyesun Jang and Ying Huang and Allen, \{James D.\} and Case, \{James Brett\} and Sutton, \{Rachel E.\} and Carnahan, \{Robert H.\} and Darling, \{Tamarand L.\} and Boon, \{Adrianus C.M.\} and Matthias Mack and Head, \{Richard D.\} and Ross, \{Ted M.\} and Crowe, \{James E.\} and Diamond, \{Michael S.\}",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = apr,
day = "1",
doi = "10.1016/j.cell.2021.02.026",
language = "English",
volume = "184",
pages = "1804--1820.e16",
journal = "Cell",
issn = "0092-8674",
number = "7",
}