Abstract
To obtain direct evidence that human natural killer cell (NK) inhibitory receptors physically interact with polymorphic determinants of major histocompatibility complex class I molecules, a receptor termed NK-associated transcript-2 has been produced as a soluble fusion protein with the human IgG1 Fc portion. This soluble receptor binds specifically to HLA-C alleles with serine 77 and asparagine 80 in cell adhesion assays.
| Original language | English |
|---|---|
| Pages (from-to) | 365-369 |
| Number of pages | 5 |
| Journal | European Journal of Immunology |
| Volume | 26 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1996 |
Keywords
- Cytotoxicity
- HLA-C
- Major histocompatibility complex
- Natural killer
- Natural killer cell receptor