To obtain direct evidence that human natural killer cell (NK) inhibitory receptors physically interact with polymorphic determinants of major histocompatibility complex class I molecules, a receptor termed NK-associated transcript-2 has been produced as a soluble fusion protein with the human IgG1 Fc portion. This soluble receptor binds specifically to HLA-C alleles with serine 77 and asparagine 80 in cell adhesion assays.

Original languageEnglish
Pages (from-to)365-369
Number of pages5
JournalEuropean Journal of Immunology
Issue number2
StatePublished - Feb 1996


  • Cytotoxicity
  • HLA-C
  • Major histocompatibility complex
  • Natural killer
  • Natural killer cell receptor


Dive into the research topics of 'Human natural killer cell inhibitory receptors bind to HLA class I molecules'. Together they form a unique fingerprint.

Cite this