Human-milk intake measured by administration of deuterium oxide to the mother: A comparison with the test-weighing technique

N. F. Butte, W. W. Wong, B. W. Patterson, C. Garza, P. D. Klein

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

A comparison was made between the dose-to-the-mother deuterium-dilution method and the conventional test-weighing technique for determining human-milk intake in five exclusively breast-fed infants and in four-breast-fed infants who received supplemental foods. After administration of 2H to the mothers human milk and infant urine were sampled over 14 d and analyzed for 2H:1H ratios by gas-isotope-ratio mass spectrometry. Infant total body water was determined by 18O dilution. The test-weighing procedure was conducted for 5 d consecutively. The intake of human milk (mean ± SD) estimated by 2H dilution was 648 ± 63 g/d and estimated by test-weighing was 636 ± 84 g/d. The mean difference between the two methods was not significantly different from 0. The 2H-dilution and test-weighing techniques provide similar estimates of human-milk intake.

Original languageEnglish
Pages (from-to)815-821
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume47
Issue number5
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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