@article{f4ca5a1a57bc4af0ab0e4dd50dc34e2b,
title = "Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses",
abstract = "The number of naive T cells decreases and susceptibility to new microbial infections increases with age. Here we describe a previously unknown subset of phenotypically naive human CD8+ T cells that rapidly secreted multiple cytokines in response to persistent viral antigens but differed transcriptionally from memory and effector T cells. The frequency of these CD8+ T cells, called 'memory T cells with a naive phenotype' (TMNP cells), increased with age and after severe acute infection and inversely correlated with the residual capacity of the immune system to respond to new infections with age. CD8+ T MNP cells represent a potential new target for the immunotherapy of persistent infections and should be accounted for and subtracted from the naive pool if truly naive T cells are needed to respond to antigens.",
author = "Vesna Pulko and Davies, {John S.} and Carmine Martinez and Lanteri, {Marion C.} and Busch, {Michael P.} and Diamond, {Michael S.} and Kenneth Knox and Bush, {Erin C.} and Sims, {Peter A.} and Shripad Sinari and Dean Billheimer and Haddad, {Elias K.} and Murray, {Kristy O.} and Wertheimer, {Anne M.} and Janko Nikolich-{\v Z}ugich",
note = "Funding Information: We thank P. Campbell of the Arizona Cancer Center, Arizona Research Laboratory Flow Cytometry Core Facility for cell sorting; the Arizona Cancer Center Support Grant (NCI grant CA 023074) for facility support; NIH Tetramer Facility for reagent preparation; K. Kedzierska (University of Melbourne) for tetramer reagents (HLA-A2 INF-GIL tetramers); and the members of the Nikolich, Kuhns, Frelinger, Wu and Schenten laboratories for insight and discussions. Supported by the US National Institutes of Health (NIAID (N01-AI00017), NHLBI (RC2HL101) and NIA (R01 AG-048021 and P30 AG008017) and by the Bowman Endowed Professorship in Medical Research (J.N.-{\v Z}.). Publisher Copyright: {\textcopyright} 2016 Nature America, Inc.",
year = "2016",
month = jul,
day = "19",
doi = "10.1038/ni.3483",
language = "English",
volume = "17",
pages = "966--975",
journal = "Nature Immunology",
issn = "1529-2908",
number = "8",
}