Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site

Laura A. Powell; Andrew Miller; Julie M. Fox; Nurgun Kose; Thomas Klose; Arthur S. Kim; Robin Bombardi; Rashika N. Tennekoon; A. Dharshan de Silva; Robert H. Carnahan; Michael S. Diamond; Michael G. Rossmann; Richard J. Kuhn; James E. Crowe

doi:10.1016/j.chom.2020.07.008

Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site

Laura A. Powell
, Andrew Miller
, Julie M. Fox
, Nurgun Kose
, Thomas Klose
, Arthur S. Kim
, Robin Bombardi
, Rashika N. Tennekoon
, A. Dharshan de Silva
, Robert H. Carnahan
, Michael S. Diamond
, Michael G. Rossmann
, Richard J. Kuhn
, James E. Crowe

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Powell et al. describe human antibodies that bind to and neutralize multiple distantly related alphaviruses. These antibodies prevent attachment to the Mxra8 alphavirus receptor. Three cryoelectron microscopy structures of Fab in complex with Ross River (RRV), Mayaro, or chikungunya viruses reveal a conserved footprint of the broadly neutralizing mAb RRV-12.

Original language	English
Pages (from-to)	699-711.e7
Journal	Cell Host and Microbe
Volume	28
Issue number	5
DOIs	https://doi.org/10.1016/j.chom.2020.07.008
State	Published - Nov 11 2020

Keywords

Chikungunya virus
Mayaro virus
O'nyong’nyong virus
Ross River virus
alphavirus
antibodies
arthritis
cross-reactivity
infectious
viral

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10.1016/j.chom.2020.07.008

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Powell, L. A., Miller, A., Fox, J. M., Kose, N., Klose, T., Kim, A. S., Bombardi, R., Tennekoon, R. N., Dharshan de Silva, A., Carnahan, R. H., Diamond, M. S., Rossmann, M. G., Kuhn, R. J., & Crowe, J. E. (2020). Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site. Cell Host and Microbe, 28(5), 699-711.e7. https://doi.org/10.1016/j.chom.2020.07.008

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title = "Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site",

abstract = "Powell et al. describe human antibodies that bind to and neutralize multiple distantly related alphaviruses. These antibodies prevent attachment to the Mxra8 alphavirus receptor. Three cryoelectron microscopy structures of Fab in complex with Ross River (RRV), Mayaro, or chikungunya viruses reveal a conserved footprint of the broadly neutralizing mAb RRV-12.",

keywords = "Chikungunya virus, Mayaro virus, O'nyong{\textquoteright}nyong virus, Ross River virus, alphavirus, antibodies, arthritis, cross-reactivity, infectious, viral",

author = "Powell, \{Laura A.\} and Andrew Miller and Fox, \{Julie M.\} and Nurgun Kose and Thomas Klose and Kim, \{Arthur S.\} and Robin Bombardi and Tennekoon, \{Rashika N.\} and \{Dharshan de Silva\}, A. and Carnahan, \{Robert H.\} and Diamond, \{Michael S.\} and Rossmann, \{Michael G.\} and Kuhn, \{Richard J.\} and Crowe, \{James E.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = nov,

day = "11",

doi = "10.1016/j.chom.2020.07.008",

language = "English",

volume = "28",

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Powell, LA, Miller, A, Fox, JM, Kose, N, Klose, T, Kim, AS, Bombardi, R, Tennekoon, RN, Dharshan de Silva, A, Carnahan, RH, Diamond, MS, Rossmann, MG, Kuhn, RJ & Crowe, JE 2020, 'Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site', Cell Host and Microbe, vol. 28, no. 5, pp. 699-711.e7. https://doi.org/10.1016/j.chom.2020.07.008

TY - JOUR

T1 - Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site

AU - Powell, Laura A.

AU - Miller, Andrew

AU - Fox, Julie M.

AU - Kose, Nurgun

AU - Klose, Thomas

AU - Kim, Arthur S.

AU - Bombardi, Robin

AU - Tennekoon, Rashika N.

AU - Dharshan de Silva, A.

AU - Carnahan, Robert H.

AU - Diamond, Michael S.

AU - Rossmann, Michael G.

AU - Kuhn, Richard J.

AU - Crowe, James E.

PY - 2020/11/11

Y1 - 2020/11/11

N2 - Powell et al. describe human antibodies that bind to and neutralize multiple distantly related alphaviruses. These antibodies prevent attachment to the Mxra8 alphavirus receptor. Three cryoelectron microscopy structures of Fab in complex with Ross River (RRV), Mayaro, or chikungunya viruses reveal a conserved footprint of the broadly neutralizing mAb RRV-12.

AB - Powell et al. describe human antibodies that bind to and neutralize multiple distantly related alphaviruses. These antibodies prevent attachment to the Mxra8 alphavirus receptor. Three cryoelectron microscopy structures of Fab in complex with Ross River (RRV), Mayaro, or chikungunya viruses reveal a conserved footprint of the broadly neutralizing mAb RRV-12.

KW - Chikungunya virus

KW - Mayaro virus

KW - O'nyong’nyong virus

KW - Ross River virus

KW - alphavirus

KW - antibodies

KW - arthritis

KW - cross-reactivity

KW - infectious

KW - viral

UR - https://www.scopus.com/pages/publications/85090057987

U2 - 10.1016/j.chom.2020.07.008

DO - 10.1016/j.chom.2020.07.008

M3 - Article

C2 - 32783883

AN - SCOPUS:85090057987

SN - 1931-3128

VL - 28

SP - 699-711.e7

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 5

ER -

Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site

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Keywords

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