TY - JOUR
T1 - Human herpesvirus 6 latent infection in patients with glioma
AU - Chi, Jing
AU - Gu, Bin
AU - Zhang, Chun
AU - Peng, Guangyong
AU - Zhou, Feng
AU - Chen, Yun
AU - Zhang, Guofeng
AU - Guo, Yidi
AU - Guo, Dandan
AU - Qin, Jian
AU - Wang, Jinfeng
AU - Li, Lingyun
AU - Wang, Fang
AU - Liu, Genyan
AU - Xie, Fangyi
AU - Feng, Dongju
AU - Zhou, Hong
AU - Huang, Xingxu
AU - Lu, Shiqiang
AU - Liu, Yingxia
AU - Hu, Weixing
AU - Yao, Kun
N1 - Funding Information:
Financial support. This work was supported by the National Natural Science Foundation of China (grants 30972784 & 81273235 to K. Y.). Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
PY - 2012/11/1
Y1 - 2012/11/1
N2 - The etiology of glioma remains unclear so far. Human herpesvirus 6 (HHV-6) might be associated with glioma, but there is no direct evidence to support this. High percentages of HHV-6 DNA and protein were detected in tissue from gliomas, compared with normal brain tissue. In addition, a strain of HHV-6A was isolated from the fluid specimens from glioma cysts. High levels of interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor , and transforming growth factor (TGF-) were detected in the cyst fluid specimens from HHV-6-positive patients with glioma. Furthermore, HHV-6A infection promoted IL-6, IL-8, and TGF- production in astrocyte cultures. Our studies strongly suggest the involvement of HHV-6 infection in the pathogenesis of glioma.
AB - The etiology of glioma remains unclear so far. Human herpesvirus 6 (HHV-6) might be associated with glioma, but there is no direct evidence to support this. High percentages of HHV-6 DNA and protein were detected in tissue from gliomas, compared with normal brain tissue. In addition, a strain of HHV-6A was isolated from the fluid specimens from glioma cysts. High levels of interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor , and transforming growth factor (TGF-) were detected in the cyst fluid specimens from HHV-6-positive patients with glioma. Furthermore, HHV-6A infection promoted IL-6, IL-8, and TGF- production in astrocyte cultures. Our studies strongly suggest the involvement of HHV-6 infection in the pathogenesis of glioma.
UR - https://www.scopus.com/pages/publications/84867512112
U2 - 10.1093/infdis/jis513
DO - 10.1093/infdis/jis513
M3 - Article
C2 - 22962688
AN - SCOPUS:84867512112
SN - 0022-1899
VL - 206
SP - 1394
EP - 1398
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 9
ER -