Human herpesvirus 6 latent infection in patients with glioma

Jing Chi, Bin Gu, Chun Zhang, Guangyong Peng, Feng Zhou, Yun Chen, Guofeng Zhang, Yidi Guo, Dandan Guo, Jian Qin, Jinfeng Wang, Lingyun Li, Fang Wang, Genyan Liu, Fangyi Xie, Dongju Feng, Hong Zhou, Xingxu Huang, Shiqiang Lu, Yingxia LiuWeixing Hu, Kun Yao

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The etiology of glioma remains unclear so far. Human herpesvirus 6 (HHV-6) might be associated with glioma, but there is no direct evidence to support this. High percentages of HHV-6 DNA and protein were detected in tissue from gliomas, compared with normal brain tissue. In addition, a strain of HHV-6A was isolated from the fluid specimens from glioma cysts. High levels of interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor , and transforming growth factor (TGF-) were detected in the cyst fluid specimens from HHV-6-positive patients with glioma. Furthermore, HHV-6A infection promoted IL-6, IL-8, and TGF- production in astrocyte cultures. Our studies strongly suggest the involvement of HHV-6 infection in the pathogenesis of glioma.

Original languageEnglish
Pages (from-to)1394-1398
Number of pages5
JournalJournal of Infectious Diseases
Issue number9
StatePublished - Nov 1 2012


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