TY - JOUR
T1 - Human gut microbiome viewed across age and geography
AU - Yatsunenko, Tanya
AU - Rey, Federico E.
AU - Manary, Mark J.
AU - Trehan, Indi
AU - Dominguez-Bello, Maria Gloria
AU - Contreras, Monica
AU - Magris, Magda
AU - Hidalgo, Glida
AU - Baldassano, Robert N.
AU - Anokhin, Andrey P.
AU - Heath, Andrew C.
AU - Warner, Barbara
AU - Reeder, Jens
AU - Kuczynski, Justin
AU - Caporaso, J. Gregory
AU - Lozupone, Catherine A.
AU - Lauber, Christian
AU - Clemente, Jose Carlos
AU - Knights, Dan
AU - Knight, Rob
AU - Gordon, Jeffrey I.
N1 - Funding Information:
Acknowledgements We thank S. Wagoner and J. Manchester for superb technical assistance, plus B. Muegge, A. Grimm, A. Hsiao, N. Griffin and P. Tarr for suggestions, and M. Ndao, T. Tinnin and R. Mkakosya for patient recruitment and/or technical assistance. This work was supported in part by grants from the National Institutes of Health (DK078669, T32-HD049338), St. Louis Children’s Discovery Institute (MD112009-201), the Howard Hughes Medical Institute, the Crohn’s and Colitis Foundation of America, and the Bill and Melinda Gates Foundation. Parts of this work used the Janus supercomputer, which is supported by National Science Foundation grant CNS-0821794, the University of Colorado, Boulder, the University of Colorado, Denver, and the National Center for Atmospheric Research.
PY - 2012/6/14
Y1 - 2012/6/14
N2 - Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize bacterial species in fecal samples from 531 individuals, plus the gene content of 110 of them. The cohort encompassed healthy children and adults from the Amazonas of Venezuela, rural Malawi and US metropolitan areas and included mono-and dizygotic twins. Shared features of the functional maturation of the gut microbiome were identified during the first three years of life in all three populations, including age-associated changes in the genes involved in vitamin biosynthesis and metabolism. Pronounced differences in bacterial assemblages and functional gene repertoires were noted between US residents and those in the other two countries. These distinctive features are evident in early infancy as well as adulthood. Our findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization.
AB - Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize bacterial species in fecal samples from 531 individuals, plus the gene content of 110 of them. The cohort encompassed healthy children and adults from the Amazonas of Venezuela, rural Malawi and US metropolitan areas and included mono-and dizygotic twins. Shared features of the functional maturation of the gut microbiome were identified during the first three years of life in all three populations, including age-associated changes in the genes involved in vitamin biosynthesis and metabolism. Pronounced differences in bacterial assemblages and functional gene repertoires were noted between US residents and those in the other two countries. These distinctive features are evident in early infancy as well as adulthood. Our findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization.
UR - http://www.scopus.com/inward/record.url?scp=84862141704&partnerID=8YFLogxK
U2 - 10.1038/nature11053
DO - 10.1038/nature11053
M3 - Review article
C2 - 22699611
AN - SCOPUS:84862141704
SN - 0028-0836
VL - 486
SP - 222
EP - 227
JO - Nature
JF - Nature
IS - 7402
ER -