TY - JOUR
T1 - Human Genetic Determinants of Viral Diseases
AU - Kenney, Adam D.
AU - Dowdle, James A.
AU - Bozzacco, Leonia
AU - McMichael, Temet M.
AU - St Gelais, Corine
AU - Panfil, Amanda R.
AU - Sun, Yan
AU - Schlesinger, Larry S.
AU - Anderson, Matthew Z.
AU - Green, Patrick L.
AU - López, Carolina B.
AU - Rosenberg, Brad R.
AU - Wu, Li
AU - Yount, Jacob S.
N1 - Funding Information:
J.S.Y. is supported by National Institutes of Health (NIH) grant AI130110. A.D.K. is supported by NIH training grant GM068412. J.A.D. is supported by the Pelotonia Fellowship Program of The Ohio State University Comprehensive Cancer Center. L.B. is supported by grant UL1TR001866 from the National Center for Advancing Translational Sciences Clinical and Translational Science Award program of the NIH. T.M.M. is supported by the Gilliam Fellowship Program of the Howard Hughes Medical Institute. L.S.S. is supported by NIH grants AI059639 and AG051428. P.L.G. is supported by NIH grant CA100730. C.B.L. is supported by NIH grant AI083284. B.R.R. is supported by NIH grants AI111825 and OD012142. L.W. is supported by NIH grants AI104483, AI120209, AI127667, and CA181997.
Publisher Copyright:
Copyright © 2017 by Annual Reviews. All rights reserved.
PY - 2017/11/27
Y1 - 2017/11/27
N2 - Much progress has been made in the identification of specific human gene variants that contribute to enhanced susceptibility or resistance to viral diseases. Herein we review multiple discoveries made with genome-wide or candidate gene approaches that have revealed significant insights into virus-host interactions. Genetic factors that have been identified include genes encoding virus receptors, receptor-modifying enzymes, and a wide variety of innate and adaptive immunity-related proteins. We discuss a range of pathogenic viruses, including influenza virus, respiratory syncytial virus, human immunodeficiency virus, human T cell leukemia virus, human papilloma virus, hepatitis B and C viruses, herpes simplex virus, norovirus, rotavirus, parvovirus, and Epstein-Barr virus. Understanding the genetic underpinnings that affect infectious disease outcomes should allow tailored treatment and prevention approaches in the future.
AB - Much progress has been made in the identification of specific human gene variants that contribute to enhanced susceptibility or resistance to viral diseases. Herein we review multiple discoveries made with genome-wide or candidate gene approaches that have revealed significant insights into virus-host interactions. Genetic factors that have been identified include genes encoding virus receptors, receptor-modifying enzymes, and a wide variety of innate and adaptive immunity-related proteins. We discuss a range of pathogenic viruses, including influenza virus, respiratory syncytial virus, human immunodeficiency virus, human T cell leukemia virus, human papilloma virus, hepatitis B and C viruses, herpes simplex virus, norovirus, rotavirus, parvovirus, and Epstein-Barr virus. Understanding the genetic underpinnings that affect infectious disease outcomes should allow tailored treatment and prevention approaches in the future.
KW - GWAS
KW - Genome-wide association study
KW - Infection
KW - SNP
KW - Single nucleotide polymorphism
KW - Virus
UR - http://www.scopus.com/inward/record.url?scp=85036526833&partnerID=8YFLogxK
U2 - 10.1146/annurev-genet-120116-023425
DO - 10.1146/annurev-genet-120116-023425
M3 - Review article
C2 - 28853921
AN - SCOPUS:85036526833
SN - 0066-4197
VL - 51
SP - 241
EP - 263
JO - Annual Review of Genetics
JF - Annual Review of Genetics
ER -