Human cardiac physiology in the phase plane: The ejection fraction to limit cycle area relation

Stephanie Eucker, Jennifer B. Lisauskas, Jasvindar Singh, Sandor J. Kovacs

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Current physiologic parameters acquired during cardiac catheterization include the systolic, minimum, and end-diastolic left ventricular pressures, the ejection fraction, and the maximum and minimum rates of pressure rise and fall. To extract additional physiologic information from the left ventricular pressure (LVP) contour, we utilized phase plane analysis (dP/dt vs P) to study LVP. One cardiac cycle generates a closed loop, or limit-cycle, in the phase plane. We hypothesized that the area of the limit-cycle is related to the external work of the heart, which is a function of both pressure and volume. We investigated the relationship between limit-cycle area (ALC) and ejection fraction (LVEF). LVP and LVEF data acquired during cardiac catheterization in ten subjects were analyzed. We observed a linear relation between ALC and LVEF with an R-value of 0.43. We conclude that new information characterizing LV function can be obtained from ALC.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
Externally publishedYes
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
ISSN (Print)0589-1019

Conference

ConferenceProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

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  • Cite this

    Eucker, S., Lisauskas, J. B., Singh, J., & Kovacs, S. J. (1999). Human cardiac physiology in the phase plane: The ejection fraction to limit cycle area relation. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 1). IEEE.