Human C3b- and C4b-regulatory proteins: a new multi-gene family

V. Michael Holers, Joe L. Cole, Douglas M. Lublin, Tsukasa Seya, John P. Atkinson

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations

Abstract

The complement cascade is regulated to prevent inappropriate activation. This regulation is targeted not only at the initiation of the cascade but also at the amplification andjunctional (C3) steps. Five glycoproteins with both complement regulatory activity and binding affinity for C3b/C4b have been characterized. In plasma these molecules are factor H(H) and C4-binding protein (C4-bp) and, on cells, they are the C3b/C4b receptor (CR1), decay-accelerating factor (DAF), and gp45-70. Here Michael Holers and his colleagues review structural, functional and genetic studies of these proteins and discuss the evidence for a new multi-gene family with a common ancestral protein.

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalImmunology today
Volume6
Issue number6
DOIs
StatePublished - Jun 1985
Externally publishedYes

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