Human astrocytes and cytokines: Tumor necrosis factor alpha and interferon gamma do not promote astrocytic proliferation

G. Moretto, A. Yoo, S. U. Kim

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12 Scopus citations

Abstract

Astrocyte cell cultures were established from human fetal brains and exposed to human recombinant tumor necrosis factor alpha (TNFα) and human recombinant interferon gamma (IFNγ), and the proliferative response was assessed by bromodeoxyuridine-immunostaining technique. TNFα showed an inhibitory activity, while IFNγ induced a slight increase in the number of astrocytes undergoing cell division. However, in both experiments differences were not statistically significant. Previous studies have demonstrated that TNFα and IFNγ are potent mitogens for adult astrocytes in both in vivo and in vitro conditions. Our results suggest that in developing brain the immunomodulatory activity of cytokines, TNFα and IFNγ, is different from that observed in adult brain.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalNeuroscience Letters
Volume151
Issue number1
DOIs
StatePublished - Mar 5 1993

Keywords

  • Astrocyte
  • Bromodeoxyuridine
  • Cytokine
  • Human
  • Interferon gamma
  • Tumor necrosis factor alpha

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