Human antibody responses to Brugia malayi antigens in brugian filariasis

Shaorong Zhang, Benwen Li, Gary J. Weil

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Human antibody responses to Brugia malayi antigens were studied with sera from a Brugia endemic area in South India. Patients with clinical filariasis had significantly higher IgE and lower IgG4 levels to adult worm antigens than people with asymptomatic microfilaraemia. Intermediate antibody levels were observed in endemic normals. A majority of sera from each clinical group contained IgG antibodies to surface antigens of infective larvae (L3) by IFAT. IgG immunoblot studies did not reveal group differences in L3 antigen recognition. IgE antibodies bound to a subset of antigens bound by IgG. IgE antibodies in sera from clinical filariasis patients preferentially bound to L3 antigens at 200, 97, 68 and 58 kDa compared with sera from microfilaria carriers. These results are consistent with prior studies of antibody responses in filariasis and add new information on the targets of IgG and IgE antibodies to L3 antigens in brugian filariasis. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)429-436
Number of pages8
JournalInternational Journal for Parasitology
Volume29
Issue number3
DOIs
StatePublished - Mar 1 1999

Keywords

  • Brugia malayi
  • ELISA
  • IFAT
  • IgE
  • IgG4
  • Infective larvae
  • Surface antigens
  • Western blot

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