Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

Lauren E. Williamson; Theron Gilliland; Pramod K. Yadav; Elad Binshtein; Robin Bombardi; Nurgun Kose; Rachel S. Nargi; Rachel E. Sutton; Clarissa L. Durie; Erica Armstrong; Robert H. Carnahan; Lauren M. Walker; Arthur S. Kim; Julie M. Fox; Michael S. Diamond; Melanie D. Ohi; William B. Klimstra; James E. Crowe

doi:10.1016/j.cell.2020.11.011

Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

Lauren E. Williamson
, Theron Gilliland
, Pramod K. Yadav
, Elad Binshtein
, Robin Bombardi
, Nurgun Kose
, Rachel S. Nargi
, Rachel E. Sutton
, Clarissa L. Durie
, Erica Armstrong
, Robert H. Carnahan
, Lauren M. Walker
, Arthur S. Kim
, Julie M. Fox
, Michael S. Diamond
, Melanie D. Ohi
, William B. Klimstra
, James E. Crowe

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Eastern equine encephalitis virus (EEEV) causes rare but serious and often fatal infection associated with inflammation of the brain. Monoclonal antibodies identified from a human survivor recognize distinct epitopes to prevent viral entry recognize, demonstrate protection as well as potent neutralization against EEEV, and may inform future vaccine design.

Original language	English
Pages (from-to)	1884-1900.e23
Journal	Cell
Volume	183
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2020.11.011
State	Published - Dec 23 2020

Keywords

Eastern equine
aerosol
encephalitis
human antibodies
monoclonal
neutralizing
prophylaxis
therapy

Access to Document

10.1016/j.cell.2020.11.011

Cite this

Williamson, L. E., Gilliland, T., Yadav, P. K., Binshtein, E., Bombardi, R., Kose, N., Nargi, R. S., Sutton, R. E., Durie, C. L., Armstrong, E., Carnahan, R. H., Walker, L. M., Kim, A. S., Fox, J. M., Diamond, M. S., Ohi, M. D., Klimstra, W. B., & Crowe, J. E. (2020). Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection. Cell, 183(7), 1884-1900.e23. https://doi.org/10.1016/j.cell.2020.11.011

@article{3ae39efc9229444981a5b65e5cc2e808,

title = "Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection",

abstract = "Eastern equine encephalitis virus (EEEV) causes rare but serious and often fatal infection associated with inflammation of the brain. Monoclonal antibodies identified from a human survivor recognize distinct epitopes to prevent viral entry recognize, demonstrate protection as well as potent neutralization against EEEV, and may inform future vaccine design.",

keywords = "Eastern equine, aerosol, encephalitis, human antibodies, monoclonal, neutralizing, prophylaxis, therapy",

author = "Williamson, \{Lauren E.\} and Theron Gilliland and Yadav, \{Pramod K.\} and Elad Binshtein and Robin Bombardi and Nurgun Kose and Nargi, \{Rachel S.\} and Sutton, \{Rachel E.\} and Durie, \{Clarissa L.\} and Erica Armstrong and Carnahan, \{Robert H.\} and Walker, \{Lauren M.\} and Kim, \{Arthur S.\} and Fox, \{Julie M.\} and Diamond, \{Michael S.\} and Ohi, \{Melanie D.\} and Klimstra, \{William B.\} and Crowe, \{James E.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = dec,

day = "23",

doi = "10.1016/j.cell.2020.11.011",

language = "English",

volume = "183",

pages = "1884--1900.e23",

journal = "Cell",

issn = "0092-8674",

number = "7",

}

Williamson, LE, Gilliland, T, Yadav, PK, Binshtein, E, Bombardi, R, Kose, N, Nargi, RS, Sutton, RE, Durie, CL, Armstrong, E, Carnahan, RH, Walker, LM, Kim, AS, Fox, JM, Diamond, MS, Ohi, MD, Klimstra, WB & Crowe, JE 2020, 'Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection', Cell, vol. 183, no. 7, pp. 1884-1900.e23. https://doi.org/10.1016/j.cell.2020.11.011

TY - JOUR

T1 - Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

AU - Williamson, Lauren E.

AU - Gilliland, Theron

AU - Yadav, Pramod K.

AU - Binshtein, Elad

AU - Bombardi, Robin

AU - Kose, Nurgun

AU - Nargi, Rachel S.

AU - Sutton, Rachel E.

AU - Durie, Clarissa L.

AU - Armstrong, Erica

AU - Carnahan, Robert H.

AU - Walker, Lauren M.

AU - Kim, Arthur S.

AU - Fox, Julie M.

AU - Diamond, Michael S.

AU - Ohi, Melanie D.

AU - Klimstra, William B.

AU - Crowe, James E.

PY - 2020/12/23

Y1 - 2020/12/23

N2 - Eastern equine encephalitis virus (EEEV) causes rare but serious and often fatal infection associated with inflammation of the brain. Monoclonal antibodies identified from a human survivor recognize distinct epitopes to prevent viral entry recognize, demonstrate protection as well as potent neutralization against EEEV, and may inform future vaccine design.

AB - Eastern equine encephalitis virus (EEEV) causes rare but serious and often fatal infection associated with inflammation of the brain. Monoclonal antibodies identified from a human survivor recognize distinct epitopes to prevent viral entry recognize, demonstrate protection as well as potent neutralization against EEEV, and may inform future vaccine design.

KW - Eastern equine

KW - aerosol

KW - encephalitis

KW - human antibodies

KW - monoclonal

KW - neutralizing

KW - prophylaxis

KW - therapy

UR - https://www.scopus.com/pages/publications/85097872090

U2 - 10.1016/j.cell.2020.11.011

DO - 10.1016/j.cell.2020.11.011

M3 - Article

C2 - 33301709

AN - SCOPUS:85097872090

SN - 0092-8674

VL - 183

SP - 1884-1900.e23

JO - Cell

JF - Cell

IS - 7

ER -

Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this