TY - JOUR
T1 - Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI
AU - Absinta, Martina
AU - Ha, Seung Kwon
AU - Nair, Govind
AU - Sati, Pascal
AU - Luciano, Nicholas J.
AU - Palisoc, Maryknoll
AU - Louveau, Antoine
AU - Zaghloul, Kareem A.
AU - Pittaluga, Stefania
AU - Kipnis, Jonathan
AU - Reich, Daniel S.
N1 - Publisher Copyright:
© 2017, eLife Sciences Publications Ltd. All rights reserved.
PY - 2017/10/3
Y1 - 2017/10/3
N2 - Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent. The topography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents. In primates, meningeal lymphatics display a typical panel of lymphatic endothelial markers by immunohistochemistry. This discovery holds promise for better understanding the normal physiology of lymphatic drainage from the central nervous system and potential aberrations in neurological diseases.
AB - Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent. The topography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents. In primates, meningeal lymphatics display a typical panel of lymphatic endothelial markers by immunohistochemistry. This discovery holds promise for better understanding the normal physiology of lymphatic drainage from the central nervous system and potential aberrations in neurological diseases.
UR - http://www.scopus.com/inward/record.url?scp=85032886612&partnerID=8YFLogxK
U2 - 10.7554/eLife.29738.001
DO - 10.7554/eLife.29738.001
M3 - Article
C2 - 28971799
AN - SCOPUS:85032886612
SN - 2050-084X
VL - 6
JO - eLife
JF - eLife
M1 - e29738
ER -