Human Adaptive Natural Killer Cells: Beyond NKG2C

Julia A. Wagner; Todd A. Fehniger

doi:10.1016/j.it.2016.05.001

Human Adaptive Natural Killer Cells: Beyond NKG2C

Julia A. Wagner, Todd A. Fehniger

Research output: Contribution to journal › Short survey › peer-review

17 Scopus citations

Abstract

Paradigm-shifting studies have identified NKG2C⁺ adaptive natural killer (NK) cells in individuals infected with cytomegalovirus. Recently in Cell Reports, Liu et al. demonstrate that NKG2C^-/- HCMV⁺ individuals also generate adaptive NK cells, and reveal CD2 as a major co-stimulatory receptor for these NK cells specialized to respond via FcγRIIIa/CD16.

Original language	English
Pages (from-to)	351-353
Number of pages	3
Journal	Trends in Immunology
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/j.it.2016.05.001
State	Published - Jun 1 2016

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title = "Human Adaptive Natural Killer Cells: Beyond NKG2C",

abstract = "Paradigm-shifting studies have identified NKG2C+ adaptive natural killer (NK) cells in individuals infected with cytomegalovirus. Recently in Cell Reports, Liu et al. demonstrate that NKG2C-/- HCMV+ individuals also generate adaptive NK cells, and reveal CD2 as a major co-stimulatory receptor for these NK cells specialized to respond via FcγRIIIa/CD16.",

author = "Wagner, {Julia A.} and Fehniger, {Todd A.}",

note = "Funding Information: This work is funded by an HHMI Medical Fellow Award (J.A.W.) and R01 AI102924 (T.A.F.). Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",

year = "2016",

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AU - Wagner, Julia A.

AU - Fehniger, Todd A.

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N2 - Paradigm-shifting studies have identified NKG2C+ adaptive natural killer (NK) cells in individuals infected with cytomegalovirus. Recently in Cell Reports, Liu et al. demonstrate that NKG2C-/- HCMV+ individuals also generate adaptive NK cells, and reveal CD2 as a major co-stimulatory receptor for these NK cells specialized to respond via FcγRIIIa/CD16.

AB - Paradigm-shifting studies have identified NKG2C+ adaptive natural killer (NK) cells in individuals infected with cytomegalovirus. Recently in Cell Reports, Liu et al. demonstrate that NKG2C-/- HCMV+ individuals also generate adaptive NK cells, and reveal CD2 as a major co-stimulatory receptor for these NK cells specialized to respond via FcγRIIIa/CD16.

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JO - Trends in Immunology

JF - Trends in Immunology

IS - 6

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Human Adaptive Natural Killer Cells: Beyond NKG2C

Abstract

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