TY - JOUR
T1 - How to improve RD productivity
T2 - The pharmaceutical industry's grand challenge
AU - Paul, Steven M.
AU - Mytelka, Daniel S.
AU - Dunwiddie, Christopher T.
AU - Persinger, Charles C.
AU - Munos, Bernard H.
AU - Lindborg, Stacy R.
AU - Schacht, Aaron L.
PY - 2010/3
Y1 - 2010/3
N2 - The pharmaceutical industry is under growing pressure from a range of environmental issues, including major losses of revenue owing to patent expirations, increasingly cost-constrained healthcare systems and more demanding regulatory requirements. In our view, the key to tackling the challenges such issues pose to both the future viability of the pharmaceutical industry and advances in healthcare is to substantially increase the number and quality of innovative, cost-effective new medicines, without incurring unsustainable RD costs. However, it is widely acknowledged that trends in industry RD productivity have been moving in the opposite direction for a number of years. Here, we present a detailed analysis based on comprehensive, recent, industry-wide data to identify the relative contributions of each of the steps in the drug discovery and development process to overall RD productivity. We then propose specific strategies that could have the most substantial impact in improving RD productivity.
AB - The pharmaceutical industry is under growing pressure from a range of environmental issues, including major losses of revenue owing to patent expirations, increasingly cost-constrained healthcare systems and more demanding regulatory requirements. In our view, the key to tackling the challenges such issues pose to both the future viability of the pharmaceutical industry and advances in healthcare is to substantially increase the number and quality of innovative, cost-effective new medicines, without incurring unsustainable RD costs. However, it is widely acknowledged that trends in industry RD productivity have been moving in the opposite direction for a number of years. Here, we present a detailed analysis based on comprehensive, recent, industry-wide data to identify the relative contributions of each of the steps in the drug discovery and development process to overall RD productivity. We then propose specific strategies that could have the most substantial impact in improving RD productivity.
UR - http://www.scopus.com/inward/record.url?scp=77649234756&partnerID=8YFLogxK
U2 - 10.1038/nrd3078
DO - 10.1038/nrd3078
M3 - Review article
C2 - 20168317
AN - SCOPUS:77649234756
SN - 1474-1776
VL - 9
SP - 203
EP - 214
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
IS - 3
ER -