How to design a study that everyone will believe: Prospective studies

Gary Gaddis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


This chapter provides an overview of various types of scientific manuscripts and research designs, beginning with the most simple, but least persuasive (clinical observations, case reports and case series), and working to the least simple, but most persuasive (prospective, randomized, double-blind clinical trials). Various strengths and weaknesses of these types of manuscripts are discussed. In order to be persuasive and to attempt to influence or change clinical practice, prospective, randomized, double-blinded clinical trials are optimal.

Original languageEnglish
Title of host publicationDoing Research in Emergency and Acute Care
Subtitle of host publicationMaking Order Out of Chaos
PublisherJohn Wiley and Sons Ltd
Number of pages6
ISBN (Electronic)9781118643440
ISBN (Print)9781118643488
StatePublished - Oct 6 2015


  • Bias
  • Case reports
  • Case series
  • Case-Control studies
  • Cohort studies
  • Observational studies
  • Randomization
  • Randomized clinical trials
  • Randomized control trials
  • blinding


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