TY - JOUR
T1 - How safe are serotonin reuptake inhibitors for depression in patients with coronary heart disease?
AU - Sheline, Yvette I.
AU - Freedland, Kenneth E.
AU - Carney, Robert M.
N1 - Funding Information:
Preparation of this manuscript was supported in part by Grant #1K07 MHO1370-01A1, NIMH, Y. Sheline, MD, PI; #2R01HL4247-04 from the National Heart, Blood and Lung Institute, NIH, R. Carney, PhD, PI; and #5R01 MH51419-02, NIMH, K. Freedland, PhD, PI.
PY - 1997/1
Y1 - 1997/1
N2 - Depression occurs frequently in patients with coronary heart disease (CHD), and confers significant risk for additional morbidity and mortality. The cardiac effects of the tricyclic antidepressants (TCAs) have been well characterized. In contrast, the cardiac effects of the selective serotonin reuptake inhibitors (SSRIs) have been less thoroughly investigated. The Medline database from 1986 to 1996 was searched for all reports of cardiac effects of SSRIs, and this literature is summarized. In addition, potential drug interactions, reports of side effects, and efficacy studies in the elderly are reviewed. Finally, recommendations are made considering the risk/benefit ratio.
AB - Depression occurs frequently in patients with coronary heart disease (CHD), and confers significant risk for additional morbidity and mortality. The cardiac effects of the tricyclic antidepressants (TCAs) have been well characterized. In contrast, the cardiac effects of the selective serotonin reuptake inhibitors (SSRIs) have been less thoroughly investigated. The Medline database from 1986 to 1996 was searched for all reports of cardiac effects of SSRIs, and this literature is summarized. In addition, potential drug interactions, reports of side effects, and efficacy studies in the elderly are reviewed. Finally, recommendations are made considering the risk/benefit ratio.
UR - http://www.scopus.com/inward/record.url?scp=0031053807&partnerID=8YFLogxK
U2 - 10.1016/S0002-9343(96)00374-9
DO - 10.1016/S0002-9343(96)00374-9
M3 - Article
C2 - 9209201
AN - SCOPUS:0031053807
SN - 0002-9343
VL - 102
SP - 54
EP - 59
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 1
ER -