TY - JOUR
T1 - How Does TGF-β Mediate Tubulointerstitial Fibrosis?
AU - Gewin, Leslie
AU - Zent, Roy
N1 - Funding Information:
Financial support: Supported in part by a Veterans Affairs Career Development Award, Biomedical Laboratory Research and Development (L.G.); the Vanderbilt Physician Scientist Development Award (L.G.); National Institutes of Health grants DK065123 , DK075594 , DK65123 , and DK083187 (all to R.Z.); an AHA established investigator award (R.Z.); a Merit Award from the Department of Veterans Affairs (R.Z.); and the George O'Brien Center Grant (R.Z.).
PY - 2012/5
Y1 - 2012/5
N2 - Tubulointerstitial fibrosis mediates the development of end-stage renal disease from renal injuries of all etiologies and is considered an important predictor of renal survival. Transforming growth factor-β (TGF-β) is one of the most important growth factors that promotes tubulointerstitial fibrosis, but the mechanisms whereby this occurs are not well defined. This is because TGF-β has pleiotropic effects that depend on the target cell type. This review discusses how TGF-β signaling in each of the relevant cell types (eg, tubular epithelium, fibroblasts) may contribute to tubulointerstitial fibrosis progression and suggests ways in which future research can improve our understanding of TGF-β-mediated tubulointerstitial fibrosis.
AB - Tubulointerstitial fibrosis mediates the development of end-stage renal disease from renal injuries of all etiologies and is considered an important predictor of renal survival. Transforming growth factor-β (TGF-β) is one of the most important growth factors that promotes tubulointerstitial fibrosis, but the mechanisms whereby this occurs are not well defined. This is because TGF-β has pleiotropic effects that depend on the target cell type. This review discusses how TGF-β signaling in each of the relevant cell types (eg, tubular epithelium, fibroblasts) may contribute to tubulointerstitial fibrosis progression and suggests ways in which future research can improve our understanding of TGF-β-mediated tubulointerstitial fibrosis.
KW - Chronic kidney disease
KW - Extracellular matrix
KW - TGF-β
KW - Tubulointerstitial fibrosis
UR - http://www.scopus.com/inward/record.url?scp=84864128173&partnerID=8YFLogxK
U2 - 10.1016/j.semnephrol.2012.04.001
DO - 10.1016/j.semnephrol.2012.04.001
M3 - Article
C2 - 22835453
AN - SCOPUS:84864128173
SN - 0270-9295
VL - 32
SP - 228
EP - 235
JO - Seminars in Nephrology
JF - Seminars in Nephrology
IS - 3
ER -