TY - JOUR
T1 - How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)?
AU - Bangham, Charles R.M.
AU - Ratner, Lee
N1 - Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - A typical person infected with the retrovirus human T-lymphotropic virus type 1 (HTLV-1) carries tens of thousands of clones of HTLV-1-infected T lymphocytes, each clone distinguished by a unique integration site of the provirus in the host genome. However, only 5% of infected people develop the malignant disease adult T cell leukaemia/lymphoma, usually more than 50 years after becoming infected. We review the host and viral factors that cause this aggressive disease.
AB - A typical person infected with the retrovirus human T-lymphotropic virus type 1 (HTLV-1) carries tens of thousands of clones of HTLV-1-infected T lymphocytes, each clone distinguished by a unique integration site of the provirus in the host genome. However, only 5% of infected people develop the malignant disease adult T cell leukaemia/lymphoma, usually more than 50 years after becoming infected. We review the host and viral factors that cause this aggressive disease.
UR - http://www.scopus.com/inward/record.url?scp=84942509244&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2015.09.004
DO - 10.1016/j.coviro.2015.09.004
M3 - Review article
C2 - 26414684
AN - SCOPUS:84942509244
SN - 1879-6257
VL - 14
SP - 93
EP - 100
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -