How does Cryptococcus get its coat?

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

During the past few decades, increasing attention has focused on pathogenic fungi both as fascinating research subjects and as the agents of serious illness in diverse patient populations. In particular, opportunistic fungi such as Cryptococcus neoformans command notice as the ranks of their immunocompromised victims grow. C. neoformans is unique among fungal pathogens for its major virulence factor, a complex polysaccharide capsule. In this article, our current understanding of the structure and biosynthesis of the capsule is reviewed, as are the many questions that remain to be answered about how Cryptococcus gets its coat. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)547-553
Number of pages7
JournalTrends in Microbiology
Volume8
Issue number12
DOIs
StatePublished - Dec 1 2000

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