TY - JOUR
T1 - How does Cryptococcus get its coat?
AU - Doering, Tamara L.
N1 - Funding Information:
I am grateful to John E. Heuser for the image in Fig. 2 . I thank Marta Feldmesser, Maor Bar-Peled, Jenny Lodge and Michael Brent for helpful comments on the manuscript, and Bill Goldman, Paul DeAngelis and members of my laboratory for productive discussions. I thank Arturo Casadevall and Guilhem Janbon for permission to cite unpublished work and Tom Kozel for directing my attention to helpful literature. I am particularly grateful to the many scientists who encouraged me to work on Cryptococcus and have been generous with time and reagents. Work in my laboratory is supported by a Burroughs Wellcome Fund New Investigator Award in Molecular Pathogenic Mycology, a GRANT award from Neose Technologies, a NSF/NIH POWRE award and NIH R01 AI49173.
PY - 2000/12/1
Y1 - 2000/12/1
N2 - During the past few decades, increasing attention has focused on pathogenic fungi both as fascinating research subjects and as the agents of serious illness in diverse patient populations. In particular, opportunistic fungi such as Cryptococcus neoformans command notice as the ranks of their immunocompromised victims grow. C. neoformans is unique among fungal pathogens for its major virulence factor, a complex polysaccharide capsule. In this article, our current understanding of the structure and biosynthesis of the capsule is reviewed, as are the many questions that remain to be answered about how Cryptococcus gets its coat. Copyright (C) 2000 Elsevier Science Ltd.
AB - During the past few decades, increasing attention has focused on pathogenic fungi both as fascinating research subjects and as the agents of serious illness in diverse patient populations. In particular, opportunistic fungi such as Cryptococcus neoformans command notice as the ranks of their immunocompromised victims grow. C. neoformans is unique among fungal pathogens for its major virulence factor, a complex polysaccharide capsule. In this article, our current understanding of the structure and biosynthesis of the capsule is reviewed, as are the many questions that remain to be answered about how Cryptococcus gets its coat. Copyright (C) 2000 Elsevier Science Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0034544608&partnerID=8YFLogxK
U2 - 10.1016/S0966-842X(00)01890-4
DO - 10.1016/S0966-842X(00)01890-4
M3 - Review article
C2 - 11115750
AN - SCOPUS:0034544608
SN - 0966-842X
VL - 8
SP - 547
EP - 553
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 12
ER -