How do short-term changes at synapses fine-tune information processing?

Achim Klug, J. Gerard G. Borst, Bruce A. Carlson, Cornelia Kopp-Scheinpflug, Vitaly A. Klyachko, Matthew A. Xu-Friedman

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Synaptic transmission is highly dependent on recent activity and can lead to depression or facilitation of synaptic strength. This phenomenon is called "short-term synaptic plasticity" and is shown at all synapses. While much work has been done to understand the mechanisms of shortterm changes in the state of synapses, short-term plasticity is often thought of as a mechanistic consequence of the design of a synapse. This review will attempt to go beyond this view and discuss how, on one hand, complex neuronal activity affects the short-term state of synapses, but also how these dynamic changes in synaptic strength affect information processing in return.

Original languageEnglish
Pages (from-to)14058-14063
Number of pages6
JournalJournal of Neuroscience
Issue number41
StatePublished - Oct 10 2012


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