How Do Meningeal Lymphatic Vessels Drain the CNS?

Daniel Raper, Antoine Louveau, Jonathan Kipnis

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations

Abstract

The many interactions between the nervous and the immune systems, which are active in both physiological and pathological states, have recently become more clearly delineated with the discovery of a meningeal lymphatic system capable of carrying fluid, immune cells, and macromolecules from the central nervous system (CNS) to the draining deep cervical lymph nodes. However, the exact localization of the meningeal lymphatic vasculature and the path of drainage from the cerebrospinal fluid (CSF) to the lymphatics remain poorly understood. Here, we discuss the potential differences between peripheral and CNS lymphatic vessels and examine the purported mechanisms of CNS lymphatic drainage, along with how these may fit into established patterns of CSF flow.

Original languageEnglish
Pages (from-to)581-586
Number of pages6
JournalTrends in Neurosciences
Volume39
Issue number9
DOIs
StatePublished - Sep 1 2016

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