CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrates.

Original languageEnglish
Pages (from-to)581-587
Number of pages7
JournalCurrent Opinion in Immunology
Issue number5
StatePublished - Oct 1998


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