How do cytotoxic lymphocytes kill their targets?

Sujan Shresta; Christine Tn Pham; Dori A. Thomas; Timothy A. Graubert; Timothy J. Ley

doi:10.1016/S0952-7915(98)80227-6

How do cytotoxic lymphocytes kill their targets?

Sujan Shresta, Christine Tn Pham, Dori A. Thomas, Timothy A. Graubert, Timothy J. Ley

Research output: Contribution to journal › Article › peer-review

342 Scopus citations

Abstract

CD8⁺ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4⁺ T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrates.

Original language	English
Pages (from-to)	581-587
Number of pages	7
Journal	Current Opinion in Immunology
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/S0952-7915(98)80227-6
State	Published - Oct 1998

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10.1016/S0952-7915(98)80227-6

Cite this

@article{574b43c29e5c447b96781bb0cf7e61cc,

title = "How do cytotoxic lymphocytes kill their targets?",

abstract = "CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrates.",

author = "Sujan Shresta and Pham, {Christine Tn} and Thomas, {Dori A.} and Graubert, {Timothy A.} and Ley, {Timothy J.}",

year = "1998",

month = oct,

doi = "10.1016/S0952-7915(98)80227-6",

language = "English",

volume = "10",

pages = "581--587",

journal = "Current Opinion in Immunology",