How chemotherapy shapes hematopoietic stem cells

Terrence N. Wong; Daniel C. Link

doi:10.1038/s41588-025-02231-0

How chemotherapy shapes hematopoietic stem cells

Research output: Contribution to journal › Comment/debate

Abstract

Two complementary studies used whole-genome sequencing of single cell-derived hematopoietic colonies to show that chemotherapy results in a marked decrease in hematopoietic stem and progenitor cell (HSPC) diversity, with the parallel evolution of multiple independent HSPCs harboring mutations in DNA damage response genes.

Original language	English
Pages (from-to)	1566-1567
Number of pages	2
Journal	Nature Genetics
Volume	57
Issue number	7
DOIs	https://doi.org/10.1038/s41588-025-02231-0
State	Published - Jul 2025

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title = "How chemotherapy shapes hematopoietic stem cells",

abstract = "Two complementary studies used whole-genome sequencing of single cell-derived hematopoietic colonies to show that chemotherapy results in a marked decrease in hematopoietic stem and progenitor cell (HSPC) diversity, with the parallel evolution of multiple independent HSPCs harboring mutations in DNA damage response genes.",

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How chemotherapy shapes hematopoietic stem cells

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