How chemotherapy shapes hematopoietic stem cells

Terrence N. Wong; Daniel C. Link

doi:10.1038/s41588-025-02231-0

How chemotherapy shapes hematopoietic stem cells

Terrence N. Wong
, Daniel C. Link

Research output: Contribution to journal › Comment/debate

Abstract

Two complementary studies used whole-genome sequencing of single cell-derived hematopoietic colonies to show that chemotherapy results in a marked decrease in hematopoietic stem and progenitor cell (HSPC) diversity, with the parallel evolution of multiple independent HSPCs harboring mutations in DNA damage response genes.

Original language	English
Pages (from-to)	1566-1567
Number of pages	2
Journal	Nature Genetics
Volume	57
Issue number	7
DOIs	https://doi.org/10.1038/s41588-025-02231-0
State	Published - Jul 2025

Access to Document

10.1038/s41588-025-02231-0

Cite this

@article{3aaa749791b84c5f9e0b747a0a459127,

title = "How chemotherapy shapes hematopoietic stem cells",

abstract = "Two complementary studies used whole-genome sequencing of single cell-derived hematopoietic colonies to show that chemotherapy results in a marked decrease in hematopoietic stem and progenitor cell (HSPC) diversity, with the parallel evolution of multiple independent HSPCs harboring mutations in DNA damage response genes.",

author = "Wong, \{Terrence N.\} and Link, \{Daniel C.\}",

note = "Publisher Copyright: {\textcopyright} Springer Nature America, Inc. 2025.",

year = "2025",

month = jul,

doi = "10.1038/s41588-025-02231-0",

language = "English",

volume = "57",

pages = "1566--1567",

journal = "Nature Genetics",

issn = "1061-4036",

number = "7",

}

TY - JOUR

T1 - How chemotherapy shapes hematopoietic stem cells

AU - Wong, Terrence N.

AU - Link, Daniel C.

N1 - Publisher Copyright: © Springer Nature America, Inc. 2025.

PY - 2025/7

Y1 - 2025/7

N2 - Two complementary studies used whole-genome sequencing of single cell-derived hematopoietic colonies to show that chemotherapy results in a marked decrease in hematopoietic stem and progenitor cell (HSPC) diversity, with the parallel evolution of multiple independent HSPCs harboring mutations in DNA damage response genes.

AB - Two complementary studies used whole-genome sequencing of single cell-derived hematopoietic colonies to show that chemotherapy results in a marked decrease in hematopoietic stem and progenitor cell (HSPC) diversity, with the parallel evolution of multiple independent HSPCs harboring mutations in DNA damage response genes.

UR - https://www.scopus.com/pages/publications/105009771685

U2 - 10.1038/s41588-025-02231-0

DO - 10.1038/s41588-025-02231-0

M3 - Comment/debate

C2 - 40596441

AN - SCOPUS:105009771685

SN - 1061-4036

VL - 57

SP - 1566

EP - 1567

JO - Nature Genetics

JF - Nature Genetics

IS - 7

ER -

How chemotherapy shapes hematopoietic stem cells

Abstract

Access to Document

Other files and links

Fingerprint

Cite this