101 Scopus citations

Abstract

A necessary step in the degradation of proteins by the ubiquitin system is recognition by the ubiquitin-protein ligases(s). Various structural features of the proteolytic substrate render it susceptible to conjugation with ubiquitin. The N-terminal residue plays a major role in this process, with distinct sites on the ligase(s) recognizing specific types of N-termini. Post-translational modification of some of these residues is required prior to their recognition. A free N terminus is not the only marker; proteins with either free or blocked N termini can be recognized via structural domains that are downstream and distinct from this residue.

Original languageEnglish
Pages (from-to)483-488
Number of pages6
JournalTrends in biochemical sciences
Volume14
Issue number12
DOIs
StatePublished - Dec 1989

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