Hotheaded: TRPV1 as Mediator of Hippocampal Synaptic Plasticity

Benedict J. Alter, Robert W. Gereau IV

Research output: Contribution to journalShort surveypeer-review

21 Scopus citations


TRPV1 is a sensory transduction channel that mediates thermal nociception and some aspects of pathological pain. In this issue of Neuron, Gibson et al. report that TRPV1 also plays important roles in hippocampal synaptic plasticity, presenting a potential challenge for TRPV1-targeted therapeutics for the treatment of pain.

Original languageEnglish
Pages (from-to)629-631
Number of pages3
Issue number5
StatePublished - Mar 13 2008


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