Hot atom chemistry and radiopharmaceuticals

Kenneth A. Krohn, Stephen M. Moerlein, Jeanne M. Link, Michael J. Welch

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations


The chemical products made in a cyclotron target are a combined result of the chemical effects of the nuclear transformation that made the radioactive atom and the bulk radiolysis in the target. This review uses some well-known examples to understand how hot atom chemistry explains the primary products from a nuclear reaction and then how radiation chemistry is exploited to set up the optimal product for radiosynthesis. It also addresses the chemical effects of nuclear decay. There are important principles that are common to hot atom chemistry and radiopharmaceutical chemistry. Both emphasize short-lived radionuclides and manipulation of high specific activity nuclides. Furthermore, they both rely on radiochromatographic separation for identification of no-carrieradded products.

Original languageEnglish
Title of host publication14th International Workshop on Targetry and Target Chemistry
Number of pages13
StatePublished - 2012
Event14th International Workshop on Targetry and Target Chemistry, WTTC 2012 - Playa del Carmen, Mexico
Duration: Aug 26 2012Aug 29 2012

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Conference14th International Workshop on Targetry and Target Chemistry, WTTC 2012
CityPlaya del Carmen


  • Hot atom chemistry
  • Nucleogenesis
  • Radiation chemistry
  • Radiopharmaceuticals


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