TY - JOUR
T1 - Host subversion by formation of intracellular bacterial communities in the urinary tract
AU - Anderson, Gregory G.
AU - Martin, Steven M.
AU - Hultgren, Scott J.
PY - 2004/10
Y1 - 2004/10
N2 - Urinary tract infections pose a serious health threat with respect to antibiotic resistance and high recurrence rates. While the host robustly responds to bacterial infiltration into the bladder, uropathogenic Escherichia coli can survive the onslaught to persist for months after initially infecting. To accomplish this feat, uropathogenic E. coli forms intracellular bacterial communities, with many biofilm-like properties, within the bladder epithelium. These communities may allow bacteria to subvert host defenses and form a persistent reservoir in the bladder.
AB - Urinary tract infections pose a serious health threat with respect to antibiotic resistance and high recurrence rates. While the host robustly responds to bacterial infiltration into the bladder, uropathogenic Escherichia coli can survive the onslaught to persist for months after initially infecting. To accomplish this feat, uropathogenic E. coli forms intracellular bacterial communities, with many biofilm-like properties, within the bladder epithelium. These communities may allow bacteria to subvert host defenses and form a persistent reservoir in the bladder.
KW - Biofilm
KW - Bladder
KW - Intracellular
KW - Recurrent
KW - Urinary tract infection
KW - Uropathogenic Escherichia coli
UR - http://www.scopus.com/inward/record.url?scp=4544330462&partnerID=8YFLogxK
U2 - 10.1016/j.micinf.2004.05.023
DO - 10.1016/j.micinf.2004.05.023
M3 - Short survey
C2 - 15380779
AN - SCOPUS:4544330462
VL - 6
SP - 1094
EP - 1101
JO - Microbes and Infection
JF - Microbes and Infection
SN - 1286-4579
IS - 12
ER -