Host subversion by formation of intracellular bacterial communities in the urinary tract

Gregory G. Anderson; Steven M. Martin; Scott J. Hultgren

doi:10.1016/j.micinf.2004.05.023

Host subversion by formation of intracellular bacterial communities in the urinary tract

Gregory G. Anderson, Steven M. Martin, Scott J. Hultgren

Research output: Contribution to journal › Short survey › peer-review

68 Scopus citations

Abstract

Urinary tract infections pose a serious health threat with respect to antibiotic resistance and high recurrence rates. While the host robustly responds to bacterial infiltration into the bladder, uropathogenic Escherichia coli can survive the onslaught to persist for months after initially infecting. To accomplish this feat, uropathogenic E. coli forms intracellular bacterial communities, with many biofilm-like properties, within the bladder epithelium. These communities may allow bacteria to subvert host defenses and form a persistent reservoir in the bladder.

Original language	English
Pages (from-to)	1094-1101
Number of pages	8
Journal	Microbes and Infection
Volume	6
Issue number	12
DOIs	https://doi.org/10.1016/j.micinf.2004.05.023
State	Published - Oct 2004

Keywords

Biofilm
Bladder
Intracellular
Recurrent
Urinary tract infection
Uropathogenic Escherichia coli

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10.1016/j.micinf.2004.05.023

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KW - Bladder

KW - Intracellular

KW - Recurrent

KW - Urinary tract infection

KW - Uropathogenic Escherichia coli

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