Host subversion by formation of intracellular bacterial communities in the urinary tract

Gregory G. Anderson, Steven M. Martin, Scott J. Hultgren

Research output: Contribution to journalShort survey

66 Scopus citations

Abstract

Urinary tract infections pose a serious health threat with respect to antibiotic resistance and high recurrence rates. While the host robustly responds to bacterial infiltration into the bladder, uropathogenic Escherichia coli can survive the onslaught to persist for months after initially infecting. To accomplish this feat, uropathogenic E. coli forms intracellular bacterial communities, with many biofilm-like properties, within the bladder epithelium. These communities may allow bacteria to subvert host defenses and form a persistent reservoir in the bladder.

Original languageEnglish
Pages (from-to)1094-1101
Number of pages8
JournalMicrobes and Infection
Volume6
Issue number12
DOIs
StatePublished - Oct 2004

Keywords

  • Biofilm
  • Bladder
  • Intracellular
  • Recurrent
  • Urinary tract infection
  • Uropathogenic Escherichia coli

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