Host immune response to influenza virus

Thomas M. Moran, Carolina B. López

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Influenza virus causes yearly epidemics and sporadic pandemics worldwide.Influenza virus is predominantly spread by the respiratory route through aerosol particles. Infection of the lungs depends upon the virus’ ability to evade innate immune mechanisms such as defensins, natural killer cells, and most importantly, type I interferons (IFN). The virus is carried from the lungs to draining lymph nodes by dendritic cells (DCs) that present peptides from viral proteins to B and T cells leading to their expansion and differentiation. The T cells mediate clearance of virus from infected tissue and the B cells generate humoral immunity that protects against reinfection with the same virus subtype. In this chapter, we will discuss the host immune response to influenza virus based on current data obtained from in vitro and in vivo systems. The interaction of the virus with innate immune mechanisms will be discussed, with a focus on the mechanisms of influenza evasion. The transition between innate and adaptive antiviral immunity and the role of DCs will be emphasized. Finally, the generation of CD4+and CD8+ T cells, antibodies, heterosubtypic immunity and the immune elements involved in efficient protection from infection will be discussed.

Original languageEnglish
Title of host publicationRNA Viruses
Subtitle of host publicationHost Gene Responses to Infections
PublisherWorld Scientific Publishing Co.
Pages131-156
Number of pages26
ISBN (Electronic)9789812833808
ISBN (Print)981283379X, 9789812833792
DOIs
StatePublished - Jan 1 2009

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