Host genetic susceptibility, dysbiosis, and viral triggers in inflammatory bowel disease

Lulu Sun, Gerardo M. Nava, Thaddeus S. Stappenbeck

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

PURPOSE OF REVIEW: Inflammatory bowel disease (IBD) is thought to occur in genetically susceptible individuals. However, environmental factors, potentially including shifts in commensal microbiota, are also required to trigger disease. This review discusses some of the recent discoveries in host susceptibility and interaction with the microbial environment, and pinpoints key areas for advancement in our understanding of IBD pathogenesis. RECENT FINDINGS: Meta-analyses of genome-wide association studies have uncovered many new exciting genes associated with susceptibility loci for IBD. In addition, improved methods to analyze the commensal microbiota pave the way to better define dysbiosis and its potential role in disease. Lastly, identification of viral triggers in experimental systems suggests a potential role for viral infection in IBD. SUMMARY: Understanding the precise microbial and immune triggers of IBD in a genetic context will hopefully lead to a better understanding of the pathogenesis of this disease and the discovery of novel therapeutic approaches, including vaccination against specific viruses.

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalCurrent opinion in gastroenterology
Volume27
Issue number4
DOIs
StatePublished - Jul 1 2011

Keywords

  • dysbiosis
  • genetic susceptibility to disease
  • inflammatory bowel disease
  • viral triggers

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