TY - JOUR
T1 - Host epithelial-viral interactions as cause and cure for asthma
AU - Holtzman, Michael J.
AU - Patel, Dhara A.
AU - Zhang, Yong
AU - Patel, Anand C.
N1 - Funding Information:
Our research on this topic is supported by grants from the National Institutes of Health (National Heart, Lung, and Blood Institute and National Institute of Allergy and Infectious Diseases).
PY - 2011/8
Y1 - 2011/8
N2 - Research on the pathogenesis of asthma has concentrated on initial stimuli, genetic susceptibilities, adaptive immune responses, and end-organ alterations (particularly in airway mucous cells and smooth muscle) as critical steps leading to disease. Recent evidence indicates that the innate immune cell response to respiratory viruses also contributes to the development of inflammatory airway disease. We further develop this concept by raising the issue that the interaction between host airway epithelial cells and respiratory viruses is another aspect of innate immunity that is also a critical determinant of asthma. We also introduce a rationale for how antiviral performance at the epithelial cell level might be improved to prevent acute infectious illness and chronic inflammatory disease caused by respiratory viruses.
AB - Research on the pathogenesis of asthma has concentrated on initial stimuli, genetic susceptibilities, adaptive immune responses, and end-organ alterations (particularly in airway mucous cells and smooth muscle) as critical steps leading to disease. Recent evidence indicates that the innate immune cell response to respiratory viruses also contributes to the development of inflammatory airway disease. We further develop this concept by raising the issue that the interaction between host airway epithelial cells and respiratory viruses is another aspect of innate immunity that is also a critical determinant of asthma. We also introduce a rationale for how antiviral performance at the epithelial cell level might be improved to prevent acute infectious illness and chronic inflammatory disease caused by respiratory viruses.
UR - http://www.scopus.com/inward/record.url?scp=80052347488&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2011.05.010
DO - 10.1016/j.coi.2011.05.010
M3 - Review article
C2 - 21703838
AN - SCOPUS:80052347488
SN - 0952-7915
VL - 23
SP - 487
EP - 494
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 4
ER -