Rift Valley Fever Virus (RVFV) is a negative sense segmented RNA virus that can cause severe hemorrhagic fever. The tri-segmented virus genome encodes for six (6) multifunctional proteins that engage host factors at a variety of different stages in the replication cycle. The S segment encodes nucleoprotein (N) and nonstructural protein S (NSs), the M segment encodes viral glycoproteins Gn and Gc as well as nonstructural protein M (NSm) and the L segment encodes the viral polymerase (L). Viral glycoproteins Gn and Gc are responsible for entry by binding to a number of host factors. Our recent studies identified a scavenger receptor, LDL receptor related protein 1 (Lrp1), as a potential pro-viral host factor for RVFV and related viruses, including Oropouche virus (OROV) infection. Coincidentally, several recent studies identified other LDL family proteins as viral entry factors and receptors for other viral families. Collectively, these observations suggest that highly conserved LDL family proteins may play a significant role in facilitating entry of viruses from several distinct families. Given the significant roles of viral and host factors during infection, characterization of these interactions is critical for therapeutic targeting with neutralizing antibodies and vaccines.

Original languageEnglish
Title of host publicationAdvances in Virus Research
EditorsMargaret Kielian, Marilyn J. Roossinck
PublisherAcademic Press Inc.
Number of pages16
ISBN (Print)9780443193583
StatePublished - Jan 2023

Publication series

NameAdvances in Virus Research
ISSN (Print)0065-3527
ISSN (Electronic)1557-8399


  • LDL receptors
  • Lrp1
  • RVFV
  • Rift Valley Fever Virus
  • Viral entry


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