TY - JOUR
T1 - Host cell-intrinsic innate immune recognition of SARS-CoV-2
AU - Madden, Emily A.
AU - Diamond, Michael S.
N1 - Funding Information:
This study was supported by grants and contracts from N.I.H. ( R01 AI157155 , HHSN75N93019C00074 , and NIAID Centers of Excellence for Influenza Research and Response ( CEIRR ) contract 75N93021C00014. E.A.M. was supported by a W.M. Keck Postdoctoral Fellowship from Washington University.
Funding Information:
M.S.D. is a consultant for Inbios, Vir Biotechnology, and Carnival Corporation, and on the Scientific Advisory Boards of Moderna and Immunome. The Diamond laboratory has received unrelated funding support in sponsored research agreements from Vir Biotechnology, Moderna, and Emergent BioSolutions.This study was supported by grants and contracts from N.I.H. (R01 AI157155, HHSN75N93019C00074, and NIAID Centers of Excellence for Influenza Research and Response (CEIRR) contract 75N93021C00014. E.A.M. was supported by a W.M. Keck Postdoctoral Fellowship from Washington University.
Publisher Copyright:
© 2021 The Author(s)
PY - 2022/2
Y1 - 2022/2
N2 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged at the end of 2019 and caused the pandemic of coronavirus disease 2019 (COVID-19). Basic and clinical investigations indicate that severe forms of COVID-19 are due in part to dysregulated immune responses to virus infection. The innate immune system is the first line of host defense against most virus infections, with pathogen recognition receptors detecting SARS-CoV-2 RNA and protein components and initiating pro-inflammatory and antiviral responses. Notwithstanding this response, SARS-CoV-2 proteins evade, inhibit, and skew innate immune signaling early in infection. In this review, we highlight the components of cell-based recognition of SARS-CoV-2 infection and the mechanisms employed by the virus to modulate these innate immune host defense pathways.
AB - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged at the end of 2019 and caused the pandemic of coronavirus disease 2019 (COVID-19). Basic and clinical investigations indicate that severe forms of COVID-19 are due in part to dysregulated immune responses to virus infection. The innate immune system is the first line of host defense against most virus infections, with pathogen recognition receptors detecting SARS-CoV-2 RNA and protein components and initiating pro-inflammatory and antiviral responses. Notwithstanding this response, SARS-CoV-2 proteins evade, inhibit, and skew innate immune signaling early in infection. In this review, we highlight the components of cell-based recognition of SARS-CoV-2 infection and the mechanisms employed by the virus to modulate these innate immune host defense pathways.
UR - http://www.scopus.com/inward/record.url?scp=85119356675&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2021.11.002
DO - 10.1016/j.coviro.2021.11.002
M3 - Review article
C2 - 34814102
AN - SCOPUS:85119356675
VL - 52
SP - 30
EP - 38
JO - Current Opinion in Virology
JF - Current Opinion in Virology
SN - 1879-6257
ER -