TY - JOUR
T1 - Host autophagy combating S. aureus
T2 - α-toxin will be tolerated
AU - Powers, Michael E.
AU - Bubeck Wardenburg, Juliane
N1 - Funding Information:
This work was supported by NIH award AI097434-01 and the Burroughs Wellcome Foundation Investigators in the Pathogenesis of Infectious Disease Fellowship to J.B.W. M.E.P. received support from NIH Grant T32 GM007183 and an American Heart Association pre-doctoral training fellowship (FP053181-01-PR).
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/4/8
Y1 - 2015/4/8
N2 - Autophagy regulates the degradation of both cellular components and invading intracellular pathogens. In this issue of Cell Host & Microbe, Maurer et al. (2015) reveal that cellular autophagy decreases host sensitivity to Staphylococcus aureus α-toxin via reduced expression of the toxin receptor ADAM10, thus rendering the host tolerant to disease.
AB - Autophagy regulates the degradation of both cellular components and invading intracellular pathogens. In this issue of Cell Host & Microbe, Maurer et al. (2015) reveal that cellular autophagy decreases host sensitivity to Staphylococcus aureus α-toxin via reduced expression of the toxin receptor ADAM10, thus rendering the host tolerant to disease.
UR - http://www.scopus.com/inward/record.url?scp=84926685313&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2015.03.010
DO - 10.1016/j.chom.2015.03.010
M3 - Short survey
C2 - 25856749
AN - SCOPUS:84926685313
SN - 1931-3128
VL - 17
SP - 419
EP - 420
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 4
ER -