TY - JOUR
T1 - Host and viral genetics of chronic infection
T2 - A mouse model of gamma- herpesvirus pathogenesis
AU - Speck, Samuel H.
AU - Virgin IV, Herbert W.
N1 - Funding Information:
HW Virgin was supported by National Institutes of Health (NIH) ROl grant AI39616 from the National Institute ofAllergy and Infectious Diseases, grant RPG-97.134-01.MBC from the American Cancer Society, and the Monsanto-Sea& Biomedical Agreement. HW Virgin and SH Speck were supported by NIH ROl grants HL60090 from the National Heart, Lung, and Blood Institute, and CA74730 from the National Cancer Institute. SH Speck was supported by NIH ROl grants CA43143, CA52004, and CA58524 from the National Cancer Institute, and the Monsanto-Searle Biomedical Agreement. We would like to acknowledge helpful discussions from members of the Speck and Virgin labs during the course of this work, as well as discussions that occurred during lab meetings shared with David Leib.
PY - 1999/8
Y1 - 1999/8
N2 - A general association of human and primate lymphotropic herpesviruses (γ-herpesviruses) with the development of lymphomas, as well as other tumors, especially in immunocompromised hosts, has been well documented. The lack of relevant small animal models for human γ-herpesviruses has impeded progress in understanding the role of these viruses in the development of chronic disease. Recent research characterizing infection of inbred strains of mice with a murine γ-herpesvirus, gamma-herpesvirus 68 (γHV68), is providing insights into viral and host factors involved in the establishment and control of chronic γ-herpesvirus infection.
AB - A general association of human and primate lymphotropic herpesviruses (γ-herpesviruses) with the development of lymphomas, as well as other tumors, especially in immunocompromised hosts, has been well documented. The lack of relevant small animal models for human γ-herpesviruses has impeded progress in understanding the role of these viruses in the development of chronic disease. Recent research characterizing infection of inbred strains of mice with a murine γ-herpesvirus, gamma-herpesvirus 68 (γHV68), is providing insights into viral and host factors involved in the establishment and control of chronic γ-herpesvirus infection.
UR - http://www.scopus.com/inward/record.url?scp=0033179090&partnerID=8YFLogxK
U2 - 10.1016/S1369-5274(99)80071-X
DO - 10.1016/S1369-5274(99)80071-X
M3 - Review article
C2 - 10458986
AN - SCOPUS:0033179090
SN - 1369-5274
VL - 2
SP - 403
EP - 409
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 4
ER -