Host and viral genetics of chronic infection: A mouse model of gamma- herpesvirus pathogenesis

Samuel H. Speck, Herbert W. Virgin IV

Research output: Contribution to journalReview articlepeer-review

106 Scopus citations

Abstract

A general association of human and primate lymphotropic herpesviruses (γ-herpesviruses) with the development of lymphomas, as well as other tumors, especially in immunocompromised hosts, has been well documented. The lack of relevant small animal models for human γ-herpesviruses has impeded progress in understanding the role of these viruses in the development of chronic disease. Recent research characterizing infection of inbred strains of mice with a murine γ-herpesvirus, gamma-herpesvirus 68 (γHV68), is providing insights into viral and host factors involved in the establishment and control of chronic γ-herpesvirus infection.

Original languageEnglish
Pages (from-to)403-409
Number of pages7
JournalCurrent Opinion in Microbiology
Volume2
Issue number4
DOIs
StatePublished - Aug 1999

Fingerprint Dive into the research topics of 'Host and viral genetics of chronic infection: A mouse model of gamma- herpesvirus pathogenesis'. Together they form a unique fingerprint.

Cite this