TY - JOUR
T1 - Hormonal regulation of intraocular pressure
AU - Kass, Michael A.
AU - Sears, Marvin L.
N1 - Funding Information:
This work was supported in part by the ConnecticutL ions Eye ResearchF oundation,I nc. and by grantsE Y-00785,E Y-00237a nd EY-00336 from the National Eye Institute, Bethesda, Maryland.
PY - 1977
Y1 - 1977
N2 - A detailed review of the hormonal effects on intraocular pressure is presented. There is evidence that corticotropin, vasopressin, thyroxin, insulin, glucocorticoids and mineralocorticoids may play a role in the physiologic regulation of intraocular pressure. Growth hormone, melanocyte stimulating hormone, progesterone, estrogen, chorionic gonadotropin and relaxin may influence intraocular pressure when administered in pharmacologic doses. Whether the key to understanding primary open-angle glaucoma lies in recognizing abnormal endocrine mechanisms, especially involving glucocorticoids, remains unclear at the present time.
AB - A detailed review of the hormonal effects on intraocular pressure is presented. There is evidence that corticotropin, vasopressin, thyroxin, insulin, glucocorticoids and mineralocorticoids may play a role in the physiologic regulation of intraocular pressure. Growth hormone, melanocyte stimulating hormone, progesterone, estrogen, chorionic gonadotropin and relaxin may influence intraocular pressure when administered in pharmacologic doses. Whether the key to understanding primary open-angle glaucoma lies in recognizing abnormal endocrine mechanisms, especially involving glucocorticoids, remains unclear at the present time.
KW - aqueous, outflow, production
KW - glaucoma
KW - hormone
KW - intraocular pressure
UR - http://www.scopus.com/inward/record.url?scp=0017648884&partnerID=8YFLogxK
U2 - 10.1016/0039-6257(77)90053-4
DO - 10.1016/0039-6257(77)90053-4
M3 - Review article
C2 - 413203
AN - SCOPUS:0017648884
SN - 0039-6257
VL - 22
SP - 153
EP - 176
JO - Survey of Ophthalmology
JF - Survey of Ophthalmology
IS - 3
ER -