Hormonal regulation of intraocular pressure

Michael A. Kass, Marvin L. Sears

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations


A detailed review of the hormonal effects on intraocular pressure is presented. There is evidence that corticotropin, vasopressin, thyroxin, insulin, glucocorticoids and mineralocorticoids may play a role in the physiologic regulation of intraocular pressure. Growth hormone, melanocyte stimulating hormone, progesterone, estrogen, chorionic gonadotropin and relaxin may influence intraocular pressure when administered in pharmacologic doses. Whether the key to understanding primary open-angle glaucoma lies in recognizing abnormal endocrine mechanisms, especially involving glucocorticoids, remains unclear at the present time.

Original languageEnglish
Pages (from-to)153-176
Number of pages24
JournalSurvey of ophthalmology
Issue number3
StatePublished - 1977


  • aqueous, outflow, production
  • glaucoma
  • hormone
  • intraocular pressure


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