Hodgkin disease after renal transplantation in childhood

Rakesh K. Goyal, Laura McEvoy, David B. Wilson

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20 Scopus citations

Abstract

Purpose: Hodgkin disease (HD) has rarely been described in organ transplant recipients. We herewith report two cases of Epstein-Barr virus (EBV) associated HD that occurred in renal transplant recipients during childhood. Patients: A 19-year-old who had a renal transplant at 12 years of age developed mixed cellularity HD 1 year following diagnosis of an EBV- associated lymphoproliferative disorder. The second case is an 18-year-old man who developed nodular sclerosing HD 7 years after renal transplantation. Results: EBV latent membrane protein-1 antigen was strongly expressed in the Hodgkin Reed-Sternberg cells in both cases. These patients achieved complete remission with standard chemotherapy without unusual toxicity. Conclusions: Renal transplant recipients on immunosuppressive therapy can develop Hodgkin disease. A review of literature on this subject with emphasis on recent molecular studies on EBV-associated cases and observed increase in incidence of HD in HIV seropositive individuals is presented.

Original languageEnglish
Pages (from-to)392-395
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume18
Issue number4
DOIs
StatePublished - 1996

Keywords

  • Chemotherapy
  • Epstein-Barr virus
  • Hodgkin disease
  • Human immunodeficiency virus
  • Lymphoproliferative disorder
  • Renal transplantation

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