HNF4A Defines Molecular Subtypes and Vulnerability to Transforming Growth Factor β-Pathway Targeted Therapies in Cancers of the Distal Esophagus

TY - JOUR

T1 - HNF4A Defines Molecular Subtypes and Vulnerability to Transforming Growth Factor β-Pathway Targeted Therapies in Cancers of the Distal Esophagus

AU - Betrnet Consortium

AU - Blum, Andrew E.

AU - Ravillah, Durgadevi

AU - Singh, Salendra

AU - Miao, Yanling

AU - Kresak, Adam M.

AU - Willis, Joseph E.

AU - Canto, Marcia I.

AU - Wang, Jean S.

AU - Shaheen, Nicholas J.

AU - Chak, Amitabh

AU - Katabathula, Ramachandra M.

AU - Khalighi, Sirvan

AU - Varadan, Vinay

AU - Guda, Kishore

N1 - Funding Information: Funding This research was supported by Public Health Service (PHS) awards: R01 CA204549 (K. Guda), U01 CA152756 (K. Guda), Case BETRNet U54 CA163060 (A. Chak, K. Guda), Case GI SPORE P50 CA150964 (A. Chak, K. Guda, A. Blum), K25 DK115904 (V. Varadan), P30 CA043703 (V. Varadan, K. Guda); Career Development Award (CDA)-2 1IK2CX001831 United States (U.S.) Department of Veterans Affairs, Biomedical Laboratory Research and Development Service (A. Blum); and the DeGregorio Family Foundation, the Savone Family, and the Esophageal Cancer Awareness Association (K. Guda), and Torrey Coast Foundation GEMINI Network (K. Guda). This work was also supported by the Tissue Resources Core and Animal Resource Center at Case Western Reserve University. Funding Information: BETRNet Consortium: Salendra Singh (Division of General Medical Sciences-Oncology, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio), Yanling Miao (Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio), Adam M. Kresak (Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio), Joseph E. Willis (Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio), Marcia I. Canto (Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland), Jean S. Wang (Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri), Nicholas J. Shaheen (Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina), and Amitabh Chak (Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio). The authors thank Dr Jason Mills and Dr Ramon Jin for sharing their technical expertise in the culturing of patient-derived samples. The authors acknowledge Wendy Brock, Rajesh Gupta, and Komal Keerthy for their assistance with patient samples, and Sarada Chadalawada and Maeve Slife for their technical contributions. The authors acknowledge the Barrett's Esophagus Translational Research Network (BETRNet) for contributions to this article and ongoing efforts to speed the translation of important research findings from laboratory and clinical studies into useful medical applications. Andrew E. Blum, MD, PhD (Conceptualization: Supporting; Data curation: Equal; Formal analysis: Equal; Funding acquisition: Equal; Investigation: Equal; Methodology: Equal; Project administration: Supporting; Resources: Supporting; Validation: Equal; Writing – original draft: Equal; Writing – review & editing: Equal). Durgadevi Ravillah, PhD (Conceptualization: Supporting; Data curation: Supporting; Formal analysis: Supporting; Investigation: Equal; Methodology: Equal; Validation: Supporting; Writing – review & editing: Supporting). Ramachandra M. Katabathula, PhD (Investigation: Supporting; Methodology: Supporting; Visualization: Supporting; Writing – review & editing: Supporting), Sirvan Khalighi, PhD (Formal analysis: Supporting; Investigation: Supporting; Visualization: Supporting; Writing – original draft: Supporting; Writing – review & editing: Supporting). Vinay Varadan, PhD (Formal analysis: Equal; Funding acquisition: Supporting; Methodology: Supporting; Software: Supporting; Visualization: Supporting; Writing – review & editing: Supporting). Kishore Guda, DVM, PhD (Conceptualization: Equal; Formal analysis: Equal; Funding acquisition: Equal; Methodology: Equal; Project administration: Lead; Resources: Lead; Supervision: Lead; Visualization: Lead; Writing – original draft: Equal; Writing – review & editing: Lead). Funding This research was supported by Public Health Service (PHS) awards: R01 CA204549 (K. Guda), U01 CA152756 (K. Guda), Case BETRNet U54 CA163060 (A. Chak, K. Guda), Case GI SPORE P50 CA150964 (A. Chak, K. Guda, A. Blum), K25 DK115904 (V. Varadan), P30 CA043703 (V. Varadan, K. Guda); Career Development Award (CDA)-2 1IK2CX001831 United States (U.S.) Department of Veterans Affairs, Biomedical Laboratory Research and Development Service (A. Blum); and the DeGregorio Family Foundation, the Savone Family, and the Esophageal Cancer Awareness Association (K. Guda), and Torrey Coast Foundation GEMINI Network (K. Guda). This work was also supported by the Tissue Resources Core and Animal Resource Center at Case Western Reserve University.

PY - 2022/11

Y1 - 2022/11

UR - http://www.scopus.com/inward/record.url?scp=85137722854&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2022.07.073

DO - 10.1053/j.gastro.2022.07.073

M3 - Short survey

C2 - 35934060

AN - SCOPUS:85137722854

SN - 0016-5085

VL - 163

SP - 1457

EP - 1460

JO - Gastroenterology

JF - Gastroenterology

IS - 5

ER -