TY - JOUR
T1 - HLA in Juvenile Diabetes
AU - Macdonald, Michael J.
AU - Curie-Cohen, Martin
AU - Reitnauer, Pamela J.
AU - Roseman, Jeffrey M.
AU - Barger, Bruce O.
AU - Murphy, Catherine C.
AU - Acton, Ronald T.
AU - Rodey, Glenn E.
AU - White, Neil
AU - Frazer, Teresa E.
AU - Santiago, Julio V.
AU - Duquesnoy, Rene J.
PY - 1980/2/14
Y1 - 1980/2/14
N2 - To the Editor: The results of Rodey and his colleagues1 confirm that the HLA antigens Dw3 and Dw4 are increased in black juvenile diabetics2 as they are in whites. Juvenile diabetes is rare in blacks in western Africa, where 99 per cent of American black slaves originated. However, 20 to 30 per cent of the gene pool of the American black population is composed of genes from whites. Since the frequency of juvenile diabetes in American blacks falls between that of African blacks and American whites, susceptibility to the disorder in American blacks can be explained by their having inherited.
AB - To the Editor: The results of Rodey and his colleagues1 confirm that the HLA antigens Dw3 and Dw4 are increased in black juvenile diabetics2 as they are in whites. Juvenile diabetes is rare in blacks in western Africa, where 99 per cent of American black slaves originated. However, 20 to 30 per cent of the gene pool of the American black population is composed of genes from whites. Since the frequency of juvenile diabetes in American blacks falls between that of African blacks and American whites, susceptibility to the disorder in American blacks can be explained by their having inherited.
UR - http://www.scopus.com/inward/record.url?scp=0019324006&partnerID=8YFLogxK
U2 - 10.1056/NEJM198002143020712
DO - 10.1056/NEJM198002143020712
M3 - Letter
C2 - 7351935
AN - SCOPUS:0019324006
SN - 0028-4793
VL - 302
SP - 405
EP - 406
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 7
ER -