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HLA-Fc fusion proteins for antigen-specific humoral suppression
Chang Liu
, Hongjie Guo
,
Brian T. Edelson
Division of Laboratory and Genomic Medicine
Institute of Clinical and Translational Sciences (ICTS)
Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)
COVID-19 Researchers
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
DBBS - Immunology
DBBS - Molecular Microbiology and Microbial Pathogenesis
Rheumatic Diseases Research Resource-Based Center
Research output
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Contribution to journal
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Review article
›
peer-review
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Keyphrases
Antigen-specific
100%
Fc-fusion Protein
100%
Human Leukocyte Antigen
100%
Antibody-mediated Rejection
20%
Human Leukocyte Antigen Antibodies
20%
Alloimmunization
20%
Antibody-producing Cells
20%
Transplantation
10%
Adaptive Immune Response
10%
Recombinant Human
10%
Protein Production
10%
Clinical Efficacy
10%
Extracellular Domain
10%
Immunoglobulin
10%
Therapeutic Potential
10%
Fusion Protein
10%
Fc Region
10%
Effector Function
10%
Antigenic Protein
10%
Therapeutic Use
10%
Allogeneic Transplantation
10%
Combination Therapy
10%
Peptide Presentation
10%
Specific Immunotherapy
10%
Engineering Challenges
10%
Transplant Outcomes
10%
Enhanced Stability
10%
Selective Targeting
10%
Long-lived Plasma Cells
10%
Selective Depletion
10%
Primary B Cells
10%
Antigen Structure
10%
Stability Functions
10%
Immunology and Microbiology
Antigen Specificity
100%
Human Leukocyte Antigen
100%
Immunoglobulin Producing Cell
25%
Immune Complex
16%
Antibody Mediated Rejection
16%
Allele
8%
B Cell
8%
Adaptive Immune System
8%
Immunotherapy
8%
Preclinical Study
8%
Antigen Structure
8%
Allograft
8%
Peptides
8%
Immunoglobulin
8%