HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population

Maribel Aguilar-Medina, Monica Escamilla-Tilch, Luis Octavio Fr�as-Castro, Geovanni Romero-Quintana, Iris Estrada-Garc�a, Sergio Estrada-Parra, Julio Granados, Eliakym Arambula Meraz, Guzman S�nchez-Schmitz, Shabaana Abdul Khader, Javier Rangel-Moreno, Rosal�o Ramos-Pay�n

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Despite the use of multidrug therapy, leprosy remains endemic in some countries. The association of several human leucocyte antigen (HLA) alleles and gene polymorphisms with leprosy has been demonstrated in many populations, but the major immune contributors associated to the spectrum of leprosy have not been defined yet. In this study, genotyping of HLA-A, -B, -DR, and -DQ alleles was performed in leprosy patients (n = 113) and control�subjects (n = 117) from the region with the highest incidence for the disease in M�xico. The odds of developing leprosy and lepromatous subtype were 2.12- and 2.74-fold higher in carriers of HLA-A*28, and 2.48- and 4.14-fold higher for leprosy and dimorphic subtype in carriers of DQB1*06. Interestingly, DQB1*07 was overrepresented in healthy individuals, compared to patients with leprosy (OR = 0.08) and the lepromatous subtype (OR = 0.06). These results suggest that HLA-A*28 is a marker for predisposition to leprosy and the lepromatous subtype and DQB1*06 to leprosy and the dimorphic subtype, while DQB1*07 might be a resistance marker in this Mestizo population.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalAnnals of Human Genetics
Volume81
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • HLA
  • Leprosy
  • Mexicans
  • susceptibility

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