TY - JOUR
T1 - HIV peripheral neuropathy progression
T2 - Protection with glucose-lowering drugs?
AU - Evans, Scott R.
AU - Lee, Anthony J.
AU - Ellis, Ronald J.
AU - Chen, Huichao
AU - Wu, Kunling
AU - Bosch, Ronald J.
AU - Clifford, David B.
PY - 2012/10
Y1 - 2012/10
N2 - The purpose of this study is to evaluate risk factors for progression from asymptomatic peripheral neuropathy (APN) to symptomatic peripheral neuropathy (SPN). Antiretroviral therapy (ART)-naïve patients initiating combination ART were followed longitudinally and screened for signs/symptoms of PN. Having APN was associated with higher odds of future SPN (odds ratio (OR)=1.58, 95 % confidence interval (CI)=(1.08, 2.29), p=0.027). Neurotoxic ART use was associated with increased odds of progression to SPN (OR= 2.16, 95 % CI=(1.21, 3.85), p=0.009) while use of glucoselowering drugs (non-insulin) was protective (OR=0.12, 95 % CI=(0.02, 0.83), p=0.031). Use of glucose-lowering drugs (non-insulin) may prevent progression from APN to SPN.
AB - The purpose of this study is to evaluate risk factors for progression from asymptomatic peripheral neuropathy (APN) to symptomatic peripheral neuropathy (SPN). Antiretroviral therapy (ART)-naïve patients initiating combination ART were followed longitudinally and screened for signs/symptoms of PN. Having APN was associated with higher odds of future SPN (odds ratio (OR)=1.58, 95 % confidence interval (CI)=(1.08, 2.29), p=0.027). Neurotoxic ART use was associated with increased odds of progression to SPN (OR= 2.16, 95 % CI=(1.21, 3.85), p=0.009) while use of glucoselowering drugs (non-insulin) was protective (OR=0.12, 95 % CI=(0.02, 0.83), p=0.031). Use of glucose-lowering drugs (non-insulin) may prevent progression from APN to SPN.
KW - Glucose-lowering drugs
KW - HIV
KW - Peripheral neuropathy
KW - Risk factors
KW - Symptomatic peripheral neuropathy
UR - http://www.scopus.com/inward/record.url?scp=84867300810&partnerID=8YFLogxK
U2 - 10.1007/s13365-012-0119-9
DO - 10.1007/s13365-012-0119-9
M3 - Article
C2 - 22806348
AN - SCOPUS:84867300810
SN - 1355-0284
VL - 18
SP - 428
EP - 433
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
IS - 5
ER -