HIV peripheral neuropathy progression: Protection with glucose-lowering drugs?

Scott R. Evans; Anthony J. Lee; Ronald J. Ellis; Huichao Chen; Kunling Wu; Ronald J. Bosch; David B. Clifford

doi:10.1007/s13365-012-0119-9

HIV peripheral neuropathy progression: Protection with glucose-lowering drugs?

Scott R. Evans, Anthony J. Lee, Ronald J. Ellis, Huichao Chen, Kunling Wu, Ronald J. Bosch, David B. Clifford

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The purpose of this study is to evaluate risk factors for progression from asymptomatic peripheral neuropathy (APN) to symptomatic peripheral neuropathy (SPN). Antiretroviral therapy (ART)-naïve patients initiating combination ART were followed longitudinally and screened for signs/symptoms of PN. Having APN was associated with higher odds of future SPN (odds ratio (OR)=1.58, 95 % confidence interval (CI)=(1.08, 2.29), p=0.027). Neurotoxic ART use was associated with increased odds of progression to SPN (OR= 2.16, 95 % CI=(1.21, 3.85), p=0.009) while use of glucoselowering drugs (non-insulin) was protective (OR=0.12, 95 % CI=(0.02, 0.83), p=0.031). Use of glucose-lowering drugs (non-insulin) may prevent progression from APN to SPN.

Original language	English
Pages (from-to)	428-433
Number of pages	6
Journal	Journal of NeuroVirology
Volume	18
Issue number	5
DOIs	https://doi.org/10.1007/s13365-012-0119-9
State	Published - Oct 2012

Keywords

Glucose-lowering drugs
HIV
Peripheral neuropathy
Risk factors
Symptomatic peripheral neuropathy

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10.1007/s13365-012-0119-9

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title = "HIV peripheral neuropathy progression: Protection with glucose-lowering drugs?",

abstract = "The purpose of this study is to evaluate risk factors for progression from asymptomatic peripheral neuropathy (APN) to symptomatic peripheral neuropathy (SPN). Antiretroviral therapy (ART)-na{\"i}ve patients initiating combination ART were followed longitudinally and screened for signs/symptoms of PN. Having APN was associated with higher odds of future SPN (odds ratio (OR)=1.58, 95 % confidence interval (CI)=(1.08, 2.29), p=0.027). Neurotoxic ART use was associated with increased odds of progression to SPN (OR= 2.16, 95 % CI=(1.21, 3.85), p=0.009) while use of glucoselowering drugs (non-insulin) was protective (OR=0.12, 95 % CI=(0.02, 0.83), p=0.031). Use of glucose-lowering drugs (non-insulin) may prevent progression from APN to SPN.",

keywords = "Glucose-lowering drugs, HIV, Peripheral neuropathy, Risk factors, Symptomatic peripheral neuropathy",

author = "Evans, {Scott R.} and Lee, {Anthony J.} and Ellis, {Ronald J.} and Huichao Chen and Kunling Wu and Bosch, {Ronald J.} and Clifford, {David B.}",

year = "2012",

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doi = "10.1007/s13365-012-0119-9",

language = "English",

volume = "18",

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T1 - HIV peripheral neuropathy progression

T2 - Protection with glucose-lowering drugs?

AU - Evans, Scott R.

AU - Lee, Anthony J.

AU - Ellis, Ronald J.

AU - Chen, Huichao

AU - Wu, Kunling

AU - Bosch, Ronald J.

AU - Clifford, David B.

PY - 2012/10

Y1 - 2012/10

N2 - The purpose of this study is to evaluate risk factors for progression from asymptomatic peripheral neuropathy (APN) to symptomatic peripheral neuropathy (SPN). Antiretroviral therapy (ART)-naïve patients initiating combination ART were followed longitudinally and screened for signs/symptoms of PN. Having APN was associated with higher odds of future SPN (odds ratio (OR)=1.58, 95 % confidence interval (CI)=(1.08, 2.29), p=0.027). Neurotoxic ART use was associated with increased odds of progression to SPN (OR= 2.16, 95 % CI=(1.21, 3.85), p=0.009) while use of glucoselowering drugs (non-insulin) was protective (OR=0.12, 95 % CI=(0.02, 0.83), p=0.031). Use of glucose-lowering drugs (non-insulin) may prevent progression from APN to SPN.

AB - The purpose of this study is to evaluate risk factors for progression from asymptomatic peripheral neuropathy (APN) to symptomatic peripheral neuropathy (SPN). Antiretroviral therapy (ART)-naïve patients initiating combination ART were followed longitudinally and screened for signs/symptoms of PN. Having APN was associated with higher odds of future SPN (odds ratio (OR)=1.58, 95 % confidence interval (CI)=(1.08, 2.29), p=0.027). Neurotoxic ART use was associated with increased odds of progression to SPN (OR= 2.16, 95 % CI=(1.21, 3.85), p=0.009) while use of glucoselowering drugs (non-insulin) was protective (OR=0.12, 95 % CI=(0.02, 0.83), p=0.031). Use of glucose-lowering drugs (non-insulin) may prevent progression from APN to SPN.

KW - Glucose-lowering drugs

KW - HIV

KW - Peripheral neuropathy

KW - Risk factors

KW - Symptomatic peripheral neuropathy

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DO - 10.1007/s13365-012-0119-9

M3 - Article

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AN - SCOPUS:84867300810

SN - 1355-0284

VL - 18

SP - 428

EP - 433

JO - Journal of NeuroVirology

JF - Journal of NeuroVirology

IS - 5

ER -

HIV peripheral neuropathy progression: Protection with glucose-lowering drugs?

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Keywords

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